Interleukin-10: Difference between revisions

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== '''Interleukin-10''' '''[[2H24]]''' ==

[[Image:2h24.png|left|~~150px~~]]

[[Image:2h24.png|left|thumb| Figure 1]]

Interleukin 10 is a ternary complex that requires specific assembly for proper function. The IL-10 complex is composed of IL-10,IL-10R1,IL-10R2. The initial step is the formation of IL-10 and IL-10R1 generating a conformational change that is required for IL-10R2 to be able to associate and form the ternary complex <ref>PMID:16982608</ref>. The completed complex activates the [http://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway JAK/STAT signaling pathway]. The completion of the ternary complex is dependent on the conformational changes that occur in the N-Terminus of the helix labelled A. The conformational changes occur when the cIL-10 binds with IL-10R1. There is a positional change of about 1 angstrom at residues between Cys-12 and Leu-46. Due to the

Interleukin 10 is a ternary complex that requires specific assembly for proper function. The IL-10 complex is composed of IL-10,IL-10R1,IL-10R2. The initial step is the formation of IL-10 and IL-10R1 generating a conformational change that is required for IL-10R2 to be able to associate and form the ternary complex <ref name="ref1">PMID:16982608</ref>. The completed complex activates the [http://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway JAK/STAT signaling pathway]. The completion of the ternary complex is dependent on the conformational changes that occur in the N-Terminus of the helix labelled A. The conformational changes occur when the cIL-10 binds with IL-10R1. There is a positional change of about 1 angstrom at residues between Cys-12 and Leu-46. Due to the

<scene name='Sandbox_165/2h24_backbone/1'>ball and stick of 2h24</scene>

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=='''IL-10'''==

Interleukin-10 is in the class [http://en.wikipedia.org/wiki/Cytokine cytokine].<ref~~>PMID:16982608<~~/~~ref~~> Interleukin-10 is a very powerful anti-inflammatory cytokine that is most commonly found to be produce by moncytes <ref>PMID:15772682</ref>. IL-10 has the ability to be a immunosupressive as well as a anti-angiogenic this means that it has the ability both promot and inhibit tumors<ref>PMID:16122836</ref>.

Interleukin-10 is in the class [http://en.wikipedia.org/wiki/Cytokine cytokine].<ref name="ref1"/> Interleukin-10 is a very powerful anti-inflammatory cytokine that is most commonly found to be produce by moncytes <ref>PMID:15772682</ref>. IL-10 has the ability to be a immunosupressive as well as a anti-angiogenic this means that it has the ability both promot and inhibit tumors<ref>PMID:16122836</ref>.

There are many types of cytokines that have many funtions such as from antiinflammatory cytokines,cytokine synthesis inhibitory factor and proinflammitory cytokines<ref>PMID:8163935</ref>.

Interleukin-10: Difference between revisions

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@@ Line 1: / Line 1: @@
 == '''Interleukin-10''' '''[[2H24]]''' ==
-[[Image:2h24.png|left|150px]]
+[[Image:2h24.png|left|thumb| Figure 1]]
-Interleukin 10 is a ternary complex that requires specific assembly for proper function. The IL-10 complex is composed of IL-10,IL-10R1,IL-10R2. The initial step is the formation of IL-10 and IL-10R1 generating a conformational change that is required for IL-10R2 to be able to associate and form the ternary complex <ref>PMID:16982608</ref>. The completed complex activates the [http://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway  JAK/STAT signaling pathway]. The completion of the ternary complex is dependent on the conformational changes that occur in the N-Terminus of the helix labelled A. The conformational changes occur when the cIL-10 binds with IL-10R1. There is a positional change of about 1 angstrom at residues between Cys-12 and Leu-46. Due to the
+Interleukin 10 is a ternary complex that requires specific assembly for proper function. The IL-10 complex is composed of IL-10,IL-10R1,IL-10R2. The initial step is the formation of IL-10 and IL-10R1 generating a conformational change that is required for IL-10R2 to be able to associate and form the ternary complex <ref name="ref1">PMID:16982608</ref>. The completed complex activates the [http://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway  JAK/STAT signaling pathway]. The completion of the ternary complex is dependent on the conformational changes that occur in the N-Terminus of the helix labelled A. The conformational changes occur when the cIL-10 binds with IL-10R1. There is a positional change of about 1 angstrom at residues between Cys-12 and Leu-46. Due to the
 <scene name='Sandbox_165/2h24_backbone/1'>ball and stick of 2h24</scene>
@@ Line 20: / Line 20: @@
 =='''IL-10'''==
-Interleukin-10 is in the class [http://en.wikipedia.org/wiki/Cytokine cytokine].<ref>PMID:16982608</ref>  Interleukin-10 is a very powerful anti-inflammatory cytokine that is most commonly found to be produce by moncytes <ref>PMID:15772682</ref>. IL-10 has the ability to be a immunosupressive as well as a anti-angiogenic this means that it has the ability both promot and inhibit tumors<ref>PMID:16122836</ref>.
+Interleukin-10 is in the class [http://en.wikipedia.org/wiki/Cytokine cytokine].<ref name="ref1"/>  Interleukin-10 is a very powerful anti-inflammatory cytokine that is most commonly found to be produce by moncytes <ref>PMID:15772682</ref>. IL-10 has the ability to be a immunosupressive as well as a anti-angiogenic this means that it has the ability both promot and inhibit tumors<ref>PMID:16122836</ref>.
 There are many types of cytokines that have many funtions such as from antiinflammatory cytokines,cytokine synthesis inhibitory factor and proinflammitory cytokines<ref>PMID:8163935</ref>.