Calcium-free Calmodulin: Difference between revisions
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==='''Calcium-bound Calmodulin'''=== | ==='''Calcium-bound Calmodulin'''=== | ||
[[Image:3cln.png| | [[Image:3cln.png|left|200px]] | ||
The structure of calcium-bound calmodulin had previously been discovered using x-ray crystallography <ref name="3CRT"/>. It was then theorized that knowledge of the structure of calcium-free calmodulin would give greater insight into the function of the protein. Attempts were made to crystallize the calcium-free (or apo) form, but to no avail, thus it was | The structure of calcium-bound calmodulin had previously been discovered using x-ray crystallography <ref name="3CRT"/>. It was then theorized that knowledge of the structure of calcium-free calmodulin would give greater insight into the function of the protein. Attempts were made to crystallize the calcium-free (or apo) form, but to no avail, thus it was decided that the only way to get a good idea of the structure would be to use several NMR experiments. | ||
==='''Calcium-bound Calmodulin'''=== | |||
[[Image:calmodulin.png|left|200px]] | [[Image:calmodulin.png|left|200px]] | ||
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==References== | ==References== | ||
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<ref group="xtra">PMID:7552748</ref><references group="xtra"/> | <ref group="xtra">PMID:7552748</ref><references group="xtra"/> | ||
Revision as of 06:23, 1 April 2010
Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Chris Truscott
Calcium-free Calmodulin
General InformationCalmodulin is a molecule that has been studied extensively in its functions within the cell, and has an important role in relaying Ca2+ signals within the cytosol. [1] It does this by binding to Ca2+, undergoing a conformational change, and may interact with various proteins within the cell.[1][2][3] Once bound to a target protein, it undergoes a further conformational change and may activate certain systems. For example, there is a Ca2+ pump in the plasma membrane pump that is activated by the binding of Ca2+-bound calmodulin, and then uses ATP to drive the Ca2+ out of the cell. [4] Calcium-bound Calmodulin The structure of calcium-bound calmodulin had previously been discovered using x-ray crystallography [3]. It was then theorized that knowledge of the structure of calcium-free calmodulin would give greater insight into the function of the protein. Attempts were made to crystallize the calcium-free (or apo) form, but to no avail, thus it was decided that the only way to get a good idea of the structure would be to use several NMR experiments. Calcium-bound Calmodulin
References
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Proteopedia Page Contributors and Editors (what is this?)
Christopher Truscott, Andrea Gorrell, Michal Harel, Alexander Berchansky, David Canner
