Group:SMART:2010 Pingry SMART Team Models: Difference between revisions
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== AdhD K249G/H255R double mutant and Self-assembly into hydrogels == | == AdhD K249G/H255R double mutant and Self-assembly into hydrogels == | ||
<applet load='AdhD_with_three_cofactors_no_H.pdb' size='400' frame='true' align='right' caption='AdhD K249G/H255R double mutant' scene=' | <applet load='AdhD_with_three_cofactors_no_H.pdb' size='400' frame='true' align='right' caption='AdhD K249G/H255R double mutant' scene='2010_Pingry_SMART_Team_Models/Adhd_model_1/1'/> | ||
'''Design description''' | |||
(β/α)<sub>8</sub> secondary structure features colored blue and red. | (β/α)<sub>8</sub> secondary structure features colored blue and red. | ||
Two mutated residues have backbone colored blue: K249G and H255R | |||
Residues involved in cofactor binding and conserved among AKR's have sidechains highlighted: S255, N252, and H255R. | |||
'''Design script:''' | '''Design script:''' | ||
