Factor VIIa: Difference between revisions
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===Kinetics of action=== | ===Kinetics of action=== | ||
In general serine proteases have a three-step kinetic mechanim: 1) formation of an enzyme-substrate (E-S) complex, 2) acylation of the active site serine, and 3) hydrolysis of the acylenzyme intermediate. A large solvent isotope effect (~3) | In general serine proteases have a three-step kinetic mechanim: 1) formation of an enzyme-substrate (E-S) complex, 2) acylation of the active site serine, and 3) hydrolysis of the acylenzyme intermediate. A large solvent isotope effect (~3) | ||
