Acetylcholine binding protein: Difference between revisions
New page: left|300px Acetylcholine binding protein (AChBP) is secreted by snails into cholinergic synapses, where it modulates transmission by binding acetylcholine (ACh). Seq... |
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= AChBP - Apo proteins = | == AChBP - Apo proteins == | ||
[[2w8e]], [[2byn]] – '''''Aplysia californica''''' (AcAChBP) <br /> | [[2w8e]], [[2byn]] – '''''Aplysia californica''''' (AcAChBP) <br /> | ||
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[[2bj0]] – '''''Bulinus truncatus''''' | [[2bj0]] – '''''Bulinus truncatus''''' | ||
= AChBP + marine biotoxins = | == AChBP + marine biotoxins == | ||
[[2wzy]] – AcAChBP + 13-desmethyl spirolide C <br /> | [[2wzy]] – AcAChBP + 13-desmethyl spirolide C <br /> | ||
[[2x00]] - AcAChBP + gymnodimine A <br /> | [[2x00]] - AcAChBP + gymnodimine A <br /> | ||
= AChBP + partial agonists; Activate the receptor with partial efficacy = | == AChBP + partial agonists; Activate the receptor with partial efficacy == | ||
[[2wn9]] - AcAChBP + 4-OH-DMXBA <br /> | [[2wn9]] - AcAChBP + 4-OH-DMXBA <br /> | ||
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[[2wnl]] – AcAChBP + anabaseine [ <br /> | [[2wnl]] – AcAChBP + anabaseine [ <br /> | ||
= AChBP+ions; Mimicking the ion conductance of the receptor = | == AChBP+ions; Mimicking the ion conductance of the receptor == | ||
[[3gua]] – AcAChBP + sulfate <br /> | [[3gua]] – AcAChBP + sulfate <br /> | ||
= AChBP+ neonicotinoids; Insecticides with lower affinity to mammals = | == AChBP+ neonicotinoids; Insecticides with lower affinity to mammals == | ||
[[3c79]] - AcAChBP + imidacloprid <br /> | [[3c79]] - AcAChBP + imidacloprid <br /> | ||
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[[2zjv]] – LsAChBP+clothianidin <br /> | [[2zjv]] – LsAChBP+clothianidin <br /> | ||
= AChBP+ non-competitive inhibitors which bind at site different than the active site and reduce the rate of receptor reaction = | == AChBP+ non-competitive inhibitors which bind at site different than the active site and reduce the rate of receptor reaction == | ||
[[2pjz]] - AcAChBP+cocaine <br /> | [[2pjz]] - AcAChBP+cocaine <br /> | ||
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[[2w8f]], [[2w8g]] – AcAChBP + in silico compounds <br /> | [[2w8f]], [[2w8g]] – AcAChBP + in silico compounds <br /> | ||
= AChBP+ peptide inhibitors = | == AChBP+ peptide inhibitors == | ||
[[2c9t]], [[2byp]], [[2br8]] - AcAChBP+conotoxin IMI <br /> | [[2c9t]], [[2byp]], [[2br8]] - AcAChBP+conotoxin IMI <br /> | ||
[[1yi5]] – AcAChBP+cobratoxin <br /> | [[1yi5]] – AcAChBP+cobratoxin <br /> | ||
= AChBP+ nicotinic agonists enhance the action of the nAChR = | == AChBP+ nicotinic agonists enhance the action of the nAChR == | ||
[[2pgz]] – AcAChBP+cocaine <br /> | [[2pgz]] – AcAChBP+cocaine <br /> | ||
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[[2bys]] - AcAChBP+lobeline <br /> | [[2bys]] - AcAChBP+lobeline <br /> | ||
= AChBP+ ligand homologs of the ligand acetylcholine = | == AChBP+ ligand homologs of the ligand acetylcholine == | ||
[[1uv6]] - LsAChBP+ carbamylcholine <br /> | [[1uv6]] - LsAChBP+ carbamylcholine <br /> | ||
[[1uw6]] - LsAChBP+nicotine <br /> | [[1uw6]] - LsAChBP+nicotine <br /> | ||
= AChBP+others = | == AChBP+others == | ||
[[2br7]] – AcAChBP+ HEPES | [[2br7]] – AcAChBP+ HEPES | ||
Revision as of 19:47, 24 April 2010
Acetylcholine binding protein (AChBP) is secreted by snails into cholinergic synapses, where it modulates transmission by binding acetylcholine (ACh). Sequence alignment revealed high similarity to the extracellular domains of the ligand-binding subunits of the nicotinic acetylcholine receptor (nAChR). The crystal structure of the AChBP homopentamer indeed provides a valuable model for identifying the nature of the ligand-binding domains and of the subunit interfaces of the nAChR. Furthermore, crystal structures of complexes of AChBP with various agonists and antagonists have provided detailed insight into the neurotransmitter binding site of nAChRs.
AChBP - Apo proteins
2w8e, 2byn – Aplysia californica (AcAChBP)
1ux2, 1i9b – Lymnaea stagnalis (LsAChBP)
2bj0 – Bulinus truncatus
AChBP + marine biotoxins
2wzy – AcAChBP + 13-desmethyl spirolide C
2x00 - AcAChBP + gymnodimine A
AChBP + partial agonists; Activate the receptor with partial efficacy
2wn9 - AcAChBP + 4-OH-DMXBA
2wnc - AcAChBP + tropisetron
2wnj - AcAChBP + DMXBA
2wnl – AcAChBP + anabaseine [
AChBP+ions; Mimicking the ion conductance of the receptor
3gua – AcAChBP + sulfate
AChBP+ neonicotinoids; Insecticides with lower affinity to mammals
3c79 - AcAChBP + imidacloprid
2zju – LsAChBP + imidacloprid
3c84 – AcAChBP + thiacloprid
2zjv – LsAChBP+clothianidin
AChBP+ non-competitive inhibitors which bind at site different than the active site and reduce the rate of receptor reaction
2pjz - AcAChBP+cocaine
2ph9 - AcAChBP+galanthamine
2w8f, 2w8g – AcAChBP + in silico compounds
AChBP+ peptide inhibitors
2c9t, 2byp, 2br8 - AcAChBP+conotoxin IMI
1yi5 – AcAChBP+cobratoxin
AChBP+ nicotinic agonists enhance the action of the nAChR
2pgz – AcAChBP+cocaine
2byr - AcAChBP+methyllycaconitine
2bys - AcAChBP+lobeline
AChBP+ ligand homologs of the ligand acetylcholine
1uv6 - LsAChBP+ carbamylcholine
1uw6 - LsAChBP+nicotine
AChBP+others
2br7 – AcAChBP+ HEPES
Proteopedia Page Contributors and Editors (what is this?)
Joel L. Sussman, Alexander Berchansky, David Canner, Michal Harel
