Conservation, Evolutionary: Difference between revisions
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==Locating Variable Patches== | ==Locating Variable Patches== | ||
In some cases, patches of highly variable (rapidly mutating) residues are also functional sites. These can also be identified with Proteopedia's ''Evolutionary Conservation'' scenes. For example, mutations in influenza hemagglutinin help the virus to evade host defenses (see [[1hgf]]). Another example is the high allelic variability of the peptide-binding groove of [[Major Histocompatibility Complex Class I]]. That variability helps the grooves of the alleles within any individual to bind a wide range of peptides, hence enabling the T lymphocyte system to defend against a wide range of pathogens, including influenza virus | In some cases, patches of highly variable (rapidly mutating) residues are also functional sites. These can also be identified preliminarily with Proteopedia's ''Evolutionary Conservation'' scenes from [[ConSurfDB vs. ConSurf|ConSurfDB]], and more definitively with conservation analysis [[ConSurfDB_vs._ConSurf#Limiting_ConSurf_Analysis_to_Proteins_of_a_Single_Function|limited to proteins of a single function]]. For example, mutations in influenza hemagglutinin help the virus to evade host defenses (see [[1hgf]]). Another example is the high allelic variability of the peptide-binding groove of [[Major Histocompatibility Complex Class I]]. That variability helps the grooves of the alleles within any individual to bind a wide range of peptides, hence enabling the T lymphocyte system to defend against a wide range of pathogens, including influenza virus. | ||
==Conservation for Domain Folding== | ==Conservation for Domain Folding== | ||
