User:Eran Hodis/Sandbox3: Difference between revisions

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<script>background [xffffff]; javascript "/cgi-bin/getlateststructure?1aoi"; set frank off; select all; spin off; wireframe off; spacefill off; trace off; set ambient 40; set specpower 40; slab off; ribbons off; cartoons off; label off; monitor off; rotate x 5; rotate y 180; rotate z -2; zoom 110; translate y -4; select dna; color cpk; spacefill; select DNA and backbone; color violet; select protein; spacefill; color tan; select t1; wireframe off; select a1; wireframe off; delay 1; select protein; wireframe off; cartoons off; spacefill off; cartoons; spacefill; select *:a, *:e; color [x63529C]; select *:b, *:f; color green; select *:c, *:g; color [xFFF200]; select *:d, *:h; color[xFC351F]; delay 1; select dna; spacefill 300; delay .2; spacefill 250; delay .2; spacefill 200; delay .2; spacefill 150; delay .2; spacefill 100; delay .2; spacefill 50; delay .2; spacefill 25; delay .2; spacefill off; wireframe off; move 0 180 0 0 0 0 0 0 4; delay 1; move 0 180 0 0 0 0 0 0 4;</script>
<script>background [xffffff]; javascript "/cgi-bin/getlateststructure?1aoi"; set frank off; select all; spin off; wireframe off; spacefill off; trace off; set ambient 40; set specpower 40; slab off; ribbons off; cartoons off; label off; monitor off; rotate x 5; rotate y 180; rotate z -2; zoom 110; translate y -4; select dna; color cpk; spacefill; select DNA and backbone; color violet; select protein; spacefill; color tan; select t1; wireframe off; select a1; wireframe off; delay 1; select protein; wireframe off; cartoons off; spacefill off; cartoons; spacefill; select *:a, *:e; color [x63529C]; select *:b, *:f; color green; select *:c, *:g; color [xFFF200]; select *:d, *:h; color[xFC351F]; delay 1; select dna; spacefill 300; delay .2; spacefill 250; delay .2; spacefill 200; delay .2; spacefill 150; delay .2; spacefill 100; delay .2; spacefill 50; delay .2; spacefill 25; delay .2; spacefill off; wireframe off; move 0 180 0 0 0 0 0 0 4; delay 1; move 0 180 0 0 0 0 0 0 4;</script>
</jmolbutton>
</jmolbutton>
</jmol>Two copies of each histone protein, <font color="gold">H2A</font>, <font color="red">H2B</font>, <font color="purple">H3</font>, and <font color="#00CC00">H4</font>, are assembled into an octameric disc. Although each monomer has an N-terminal tail that projects from the histone core, the structure at left shows only a single tail from one <span class="style9">H3</span> monomer.
</jmol>Two copies of each histone protein, <font color="gold">H2A</font>, <font color="red">H2B</font>, <font color="purple">H3</font>, and <font color="#00CC00">H4</font>, are assembled into an octameric disc. Although each monomer has an N-terminal tail that projects from the histone core, the structure at left shows only a single tail from one <font color="purple">H3</font> monomer.
 
 
<jmol>
<jmolbutton>
<script>background [xffffff]; javascript "/cgi-bin/getlateststructure?1aoi"; set frank off; select all; spin off; wireframe off; spacefill off; trace off; set ambient 40; set specpower 40; slab off; ribbons off; cartoons off; label off; monitor off; rotate x 5; rotate y 180; rotate z -2; zoom 110; translate y -4; select dna; color cpk; spacefill; select DNA and backbone; color violet; select protein; spacefill; color tan; select t1; wireframe off; select a1; wireframe off; delay 1; select protein; wireframe off; cartoons off; spacefill off; cartoons; spacefill; select *:a, *:e; color [x63529C]; select *:b, *:f; color green; select *:c, *:g; color [xFFF200]; select *:d, *:h; color[xFC351F]; delay 1; select dna; spacefill 300; delay .2; spacefill 250; delay .2; spacefill 200; delay .2; spacefill 150; delay .2; spacefill 100; delay .2; spacefill 50; delay .2; spacefill 25; delay .2; spacefill off; wireframe off; select protein; spacefill 300; delay .2; spacefill 250; delay .2; spacefill 200; delay .2; spacefill 150; delay .2; spacefill 100; delay .2; spacefill 50; delay .2; spacefill 25; delay .2; spacefill off; wireframe off; delay.5; define not_g *:c, *:a, *:e, *:b, *:f, *:h, *:d; select not_g and helix; trace 30; cartoons 350; delay .1; cartoons 325; delay .1; cartoons 300; delay .1; cartoons 275; delay .1; cartoons 250; delay .1; cartoons 200; delay .1; cartoons 175; delay .1; cartoons 150; delay .1; cartoons 125; delay .1; cartoons 100; delay .1; cartoons 75; delay .1; select not_g; cartoons 50; delay .1; cartoons 30; trace 30; delay .1; cartoons off; trace 10; delay .1; trace off; restrict 27-97:g; wireframe off; cartoons; color tan; select 26-38; color gold; select 39-45; color purple; select 46-73; color deepskyblue; select 74-78; color red; select 79-97; color [x808080]; select atomno= 5451; label off; select atomno= 5150; label Alpha 2; color label deepskyblue; select atomno= 1756; label Loop 1; select atomno= 4976; label Alpha 1; select atomno= 5374; label Alpha 3; select atomno= 5284; label Loop 2; delay 1; moveto  4.0 { -18 -999 44 179.91}  310.0 35.2 -46.93  {41.766502 99.7805 8.903} 82.66305  {0.0 0.0 0.0} 114.375595 186.82755 50.0; delay 1; move 0 -90 0 0 0 0 0 0 3; delay 1; move 0 90 0 0 0 0 0 0 3</script>
</jmolbutton>
</jmol>All four histone proteins share a highly similar structural motif, the histone fold, comprising three alpha helices connected by two loops (shown here for <font color="gold">H2A</font>):
<font color="gold">alpha1</font>-<font color="#990099">loop1</font>-<font color="lightblue">alpha2</font>-<font color="#FF0000">loop2-<font color="#808080">alpha3</font>