3lu9: Difference between revisions
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===Crystal structure of human thrombin mutant S195A in complex with the extracellular fragment of human PAR1=== | ===Crystal structure of human thrombin mutant S195A in complex with the extracellular fragment of human PAR1=== | ||
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==Disease== | ==Disease== | ||
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<ref group="xtra">PMID:15152000</ref><references group="xtra"/> | <ref group="xtra">PMID:20236938</ref><ref group="xtra">PMID:15152000</ref><references group="xtra"/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
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[[Category: Zymogen]] | [[Category: Zymogen]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:40:54 2010'' | ||
Revision as of 04:36, 26 May 2010
Crystal structure of human thrombin mutant S195A in complex with the extracellular fragment of human PAR1
Template:ABSTRACT PUBMED 20236938
Disease
Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]
About this Structure
3LU9 is a 6 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Gandhi PS, Chen Z, Di Cera E. Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1. J Biol Chem. 2010 May 14;285(20):15393-8. Epub 2010 Mar 17. PMID:20236938 doi:10.1074/jbc.M110.115337
- Pineda AO, Carrell CJ, Bush LA, Prasad S, Caccia S, Chen ZW, Mathews FS, Di Cera E. Molecular dissection of Na+ binding to thrombin. J Biol Chem. 2004 Jul 23;279(30):31842-53. Epub 2004 May 19. PMID:15152000 doi:https://dx.doi.org/10.1074/jbc.M401756200
Page seeded by OCA on Wed May 26 08:40:54 2010
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Thrombin
- Cera, E Di.
- Chen, Z.
- Gandhi, P S.
- Acute phase
- Blood coagulation
- Calcium
- Cell membrane
- Cleavage on pair of basic residue
- Disease mutation
- Disulfide bond
- G-protein coupled receptor
- Gamma-carboxyglutamic acid
- Glycoprotein
- Hydrolase
- Kringle
- Membrane
- Pharmaceutical
- Phosphoprotein
- Polymorphism
- Protease
- Receptor
- Secreted
- Serine protease
- Transducer
- Transmembrane
- Zymogen
