User:Wayne Decatur/Suppression of RNA Silencing by Viruses: Difference between revisions

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For a general introduction to RNA interference, see [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=rna%20interference&rid=mboc4.section.1363#1399 the pertinent section] in [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mboc4 Molecular Biology of the Cell by Alberts et al.] or [http://www.hhmi.org/biointeractive/rna/rnai/index.html the Howard Hughes Medical Institute interactive online resource on the RNAi mechanism and overview of key scientific findings] or [http://www.nature.com/focus/rnai/animations/index.html an animation from Nature Publishing Group on the mechanism of RNA Interference].
For a general introduction to RNA interference, see [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=rna%20interference&rid=mboc4.section.1363#1399 the pertinent section] in [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mboc4 Molecular Biology of the Cell by Alberts et al.] or [http://www.hhmi.org/biointeractive/rna/rnai/index.html the Howard Hughes Medical Institute interactive online resource on the RNAi mechanism and overview of key scientific findings] or [http://www.nature.com/focus/rnai/animations/index.html an animation from Nature Publishing Group on the mechanism of RNA Interference].


Three structures, in particular, have provided insight into the basis for the molecular interactions involved in suppression of gene silencing (RNAi) by plant and animal viruses. The three different proteins in these examples bind to double stranded RNA by three different mechanisms: [[Tomato aspermy virus protein 2b Suppression of RNA Silencing|one]] to the major groove, one to the minor groove, and [[Plant Viral Protein p19 Suppression of RNA Silencing|one]] using "molecular calipers". Separate in-depth entries for each of these studies exist in Proteopedia:
Three structures, in particular, have provided insight into the basis for the molecular interactions involved in suppression of gene silencing (RNAi) by plant and animal viruses. Interestingly, the three proteins in these examples each employ a unique solution to bind the double stranded silencing RNA: [[Tomato aspermy virus protein 2b Suppression of RNA Silencing|one]] interacts with the major groove, [[Flock house virus B2 protein Suppression of RNA Silencing|one]] interacts mainly with the minor groove, and [[Plant Viral Protein p19 Suppression of RNA Silencing|one]] uses "molecular calipers" to measure the size of the silecing RNA. In Proteopedia, there are separate detailed entries for each of these structures:


::::::*[[Plant Viral Protein p19 Suppression of RNA Silencing]]
::::::*[[Plant Viral Protein p19 Suppression of RNA Silencing]]
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