2bkt: Difference between revisions
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[[Image:2bkt.gif|left|200px]]<br /> | [[Image:2bkt.gif|left|200px]]<br /><applet load="2bkt" size="450" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2bkt" size="450" color="white" frame="true" align="right" spinBox="true" | |||
caption="2bkt, resolution 2.3Å" /> | caption="2bkt, resolution 2.3Å" /> | ||
'''CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX'''<br /> | '''CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2BKT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with RPF as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] | 2BKT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with RPF as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] Known structural/functional Site: <scene name='pdbsite=AC1:Rpf Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BKT OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: renin]] | [[Category: renin]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:50:28 2007'' | ||
Revision as of 16:40, 18 December 2007
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CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX
Overview
We have found that both enantiomeric configurations of the, 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin, inhibition activity and similar SAR patterns. This enantiomeric, flexibility is in contrast to a previously reported, 3-alkoxymethyl-4-arylpiperidine scaffold.
Disease
Known diseases associated with this structure: Hyperproreninemia OMIM:[179820], Renal tubular dysgenesis OMIM:[179820]
About this Structure
2BKT is a Single protein structure of sequence from Homo sapiens with RPF as ligand. Active as Renin, with EC number 3.4.23.15 Known structural/functional Site: AC1. Full crystallographic information is available from OCA.
Reference
Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors., Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Zhang E, Edmunds JJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2371-4. PMID:15837327
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