2boj: Difference between revisions
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[[Image:2boj.gif|left|200px]]<br /> | [[Image:2boj.gif|left|200px]]<br /><applet load="2boj" size="450" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2boj" size="450" color="white" frame="true" align="right" spinBox="true" | |||
caption="2boj, resolution 1.80Å" /> | caption="2boj, resolution 1.80Å" /> | ||
'''CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN (PA-IIL) COMPLEXED WITH METHYL-B-D-ARABINOPYRANOSIDE'''<br /> | '''CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN (PA-IIL) COMPLEXED WITH METHYL-B-D-ARABINOPYRANOSIDE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2BOJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with CA, SO4 and ARW as [http://en.wikipedia.org/wiki/ligands ligands]. | 2BOJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with CA, SO4 and ARW as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Ca Binding Site For Chain D'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BOJ OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: lewis a]] | [[Category: lewis a]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:54:07 2007'' | ||
Revision as of 16:44, 18 December 2007
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN (PA-IIL) COMPLEXED WITH METHYL-B-D-ARABINOPYRANOSIDE
Overview
The lectin from Pseudomonas aeruginosa (PA-IIL) is involved in host, recognition and biofilm formation. Lectin not only displays an unusually, high affinity for fucose but also binds to L-fucose, L-galactose and, D-arabinose that differ only by the group at position 5 of the sugar ring., Isothermal calorimetry experiments provided precise determination of, affinity for the three methyl-glycosides and revealed a large enthalpy, contribution. The crystal structures of the complexes of PA-IIL with, L-galactose and Met-beta-D-arabinoside have been determined and compared, with the PA-IIL/fucose complex described previously. A combination of the, structures and thermodynamics provided clues for the role of the, hydrophobic group in affinity.
About this Structure
2BOJ is a Single protein structure of sequence from Pseudomonas aeruginosa with CA, SO4 and ARW as ligands. Known structural/functional Site: AC1. Full crystallographic information is available from OCA.
Reference
Binding of different monosaccharides by lectin PA-IIL from Pseudomonas aeruginosa: thermodynamics data correlated with X-ray structures., Sabin C, Mitchell EP, Pokorna M, Gautier C, Utille JP, Wimmerova M, Imberty A, FEBS Lett. 2006 Feb 6;580(3):982-7. Epub 2006 Jan 19. PMID:16438968
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