User:Martha Blakely/Sandbox 1: Difference between revisions
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<applet load='1GOS' size='300' align= 'right' caption=' | <applet load='1GOS' size='300' align= 'right' caption='Monoamine oxidase B is a dimer.'/> | ||
Monoamine oxidase B (MAO-B) is a mitochondrial outer-membrane flavoenzyme. It is one of two isozymes (MOA-A is the other), which catalyzes the oxidative deamination of amine neurotransmitters, including [http://en.wikipedia.org/wiki/Serotonin serotonin], [http://en.wikipedia.org/wiki/Dopamine dopamine], and [http://en.wikipedia.org/wiki/Epinephrine epinephrine]. The flavin-dependent enzymes use O<sub>2</sub> as an electron acceptor in the catalytic pathway which includes hydrogen peroxide, H<sub>2</sub>O<sub>2</sub>, as a product. Increased H<sub>2</sub>O<sub>2</sub> levels promote apoptotic signaling of cells which can be related to health problems of the brain like [http://en.wikipedia.org/wiki/Parkinson%27s_disease Parkinson’s Disease]. Inhibitors of MAO-B such as [http://en.wikipedia.org/wiki/Rasagiline rasagiline] have been developed in order to protect the brain. | Monoamine oxidase B (MAO-B) is a mitochondrial outer-membrane flavoenzyme. It is one of two isozymes (MOA-A is the other), which catalyzes the oxidative deamination of amine neurotransmitters, including [http://en.wikipedia.org/wiki/Serotonin serotonin], [http://en.wikipedia.org/wiki/Dopamine dopamine], and [http://en.wikipedia.org/wiki/Epinephrine epinephrine]. The flavin-dependent enzymes use O<sub>2</sub> as an electron acceptor in the catalytic pathway which includes hydrogen peroxide, H<sub>2</sub>O<sub>2</sub>, as a product. Increased H<sub>2</sub>O<sub>2</sub> levels promote apoptotic signaling of cells which can be related to health problems of the brain like [http://en.wikipedia.org/wiki/Parkinson%27s_disease Parkinson’s Disease]. Inhibitors of MAO-B such as [http://en.wikipedia.org/wiki/Rasagiline rasagiline] have been developed in order to protect the brain. | ||
