TBX3: Difference between revisions
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=Interaction with DNA= | =Interaction with DNA= | ||
Loops that protrude from one end of the β barrel and the C-terminal helical extension contact both the major and minor grooves of the DNA. Strand B contains residues Arg130 and Arg131, and recognises the major groove. Arg130 is the only residue in direct contact with a DNA base in the major groove and recognises N7 and H<sub>2</sub>O.O6 of guanine (base pair 5) and the corresponding phosphate. Arg131 interacts with the DNA backbone mediated by water. | Loops that protrude from one end of the β barrel and the C-terminal helical extension contact both the major and minor grooves of the DNA. Strand B contains residues <scene name='User:Helen_Ginn/310c_arg130-131/1'>Arg130 and Arg131</scene>, and recognises the major groove. Arg130 is the only residue in direct contact with a DNA base in the major groove and recognises N7 and H<sub>2</sub>O.O6 of guanine (base pair 5) and the corresponding phosphate. Arg131 interacts with the DNA backbone mediated by water. | ||
==gα3 loop interaction with DNA== | ==gα3 loop interaction with DNA== | ||
