Tropomyosin: Difference between revisions
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[[Image:1c1g.png|left|300px]] | [[Image:1c1g.png|left|300px]] | ||
{{STRUCTURE_1c1g| PDB=1c1g | SIZE=400| SCENE= |CAPTION=Tropomyosin from ''Sus scrofa'', [[1c1g]] }} | {{STRUCTURE_1c1g| PDB=1c1g | SIZE=400| SCENE=Tropomyosin/Cv/1 |CAPTION=Tropomyosin from [http://en.wikipedia.org/wiki/Sus_scrofa ''Sus scrofa''], [[1c1g]] }} | ||
'''3D Structure of Tropomyosin''' <br /> | '''3D Structure of Tropomyosin''' <br /> | ||
The image at the | The image at the left is a Tropomyosin from [http://en.wikipedia.org/wiki/Sus_scrofa ''Sus scrofa''] ([[1c1g]]). | ||
{{Clear}} | {{Clear}} | ||
== Tropomyosin == | == Tropomyosin == | ||
Tropomyosin (TPM) has a 4-helix coiled dimer structure. It regulates the binding of myosin thus regulating muscle contraction. In its locked conformation it binds troponin T (TnnT) and prevents the binding of myosin to actin. When Ca+ atoms bind to TnnT, the TPM assumes an open conformation and myosin can bind to actin. You can <scene name='Tropomyosin/Cv/2'>enlarge the image</scene> at the right for clarity. | |||
== 3D Structures of Tropomyosin == | == 3D Structures of Tropomyosin == | ||
3mtu, 3mud – cTPM alpha-1 – chicken<br /> | [[3mtu]], [[3mud]] – cTPM alpha-1 – chicken<br /> | ||
1ic2 - cTPM alpha-1 (mutant)<br /> | [[1ic2]] - cTPM alpha-1 (mutant)<br /> | ||
2w49 – cTnnC+cTnnT+cTnnI+cTPM alpha-1+cActin<br /> | [[2w49]] – cTnnC+cTnnT+cTnnI+cTPM alpha-1+cActin<br /> | ||
2z5h – yTPM alpha-1 N-terminal+C-terminal+GNC4+TnnT – yeast<br /> | [[2z5h]] – yTPM alpha-1 N-terminal+C-terminal+GNC4+TnnT – yeast<br /> | ||
2z5i - yTPM alpha-1 N-terminal+C-terminal+GNC4<br /> | [[2z5i]] - yTPM alpha-1 N-terminal+C-terminal+GNC4<br /> | ||
2efr, 2efs, 2d3e - rTPM alpha-1 C-terminal+GNC4 – rabbit<br /> | [[2efr]], [[2efs]], [[2d3e]] - rTPM alpha-1 C-terminal+GNC4 – rabbit<br /> | ||
1kql - TPM alpha-1 C-terminal+GNC4 - rat<br /> | [[1kql]] - TPM alpha-1 C-terminal+GNC4 - rat<br /> | ||
2b9c – TPM mid region – rat<br /> | [[2b9c]] – TPM mid region – rat<br /> | ||
1c1g – TPM – pig<br /> | [[1c1g]] – TPM – pig<br /> | ||
2tma – TPM - model<br /> | [[2tma]] – TPM - model<br /> | ||
Revision as of 12:35, 22 July 2010
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| Tropomyosin from Sus scrofa, 1c1g | |||||||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
3D Structure of Tropomyosin
The image at the left is a Tropomyosin from Sus scrofa (1c1g).
Tropomyosin
Tropomyosin (TPM) has a 4-helix coiled dimer structure. It regulates the binding of myosin thus regulating muscle contraction. In its locked conformation it binds troponin T (TnnT) and prevents the binding of myosin to actin. When Ca+ atoms bind to TnnT, the TPM assumes an open conformation and myosin can bind to actin. You can enlarge the image at the right for clarity.
3D Structures of Tropomyosin
3mtu, 3mud – cTPM alpha-1 – chicken
1ic2 - cTPM alpha-1 (mutant)
2w49 – cTnnC+cTnnT+cTnnI+cTPM alpha-1+cActin
2z5h – yTPM alpha-1 N-terminal+C-terminal+GNC4+TnnT – yeast
2z5i - yTPM alpha-1 N-terminal+C-terminal+GNC4
2efr, 2efs, 2d3e - rTPM alpha-1 C-terminal+GNC4 – rabbit
1kql - TPM alpha-1 C-terminal+GNC4 - rat
2b9c – TPM mid region – rat
1c1g – TPM – pig
2tma – TPM - model
Proteopedia Page Contributors and Editors (what is this?)
Gregory Hoeprich, Alexander Berchansky, David Canner, Joel L. Sussman, Jaime Prilusky, Michal Harel
