Lipase: Difference between revisions
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==Lipase Catalytic Mechanism== | ==Lipase Catalytic Mechanism== | ||
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Although a diverse array of lipase enzymes are found in nature, occupying diverse protein scaffolds, most are built upon an alpha/beta hydrolase fold<ref>PMID: 1678899</ref><ref>PMID:1409539 </ref> and possess a [[chymotrypsin]]-like <scene name='Lipase/Catalytic_site_outerview/1'>catalytic triad </scene>comprised of an acidic residue, a histidine, and a serine nucleophile. In the case of the images above of a horse pancreatic lipase, the catalytic triad is comprised of <scene name='Lipase/Catalytic_triad/4'>Ser 152, Asp 176 and His 263. </scene><ref>PMID:8182745</ref> | Although a diverse array of lipase enzymes are found in nature, occupying diverse protein scaffolds, most are built upon an alpha/beta hydrolase fold<ref>PMID: 1678899</ref><ref>PMID:1409539 </ref> and possess a [[chymotrypsin]]-like <scene name='Lipase/Catalytic_site_outerview/1'>catalytic triad </scene>comprised of an acidic residue, a histidine, and a serine nucleophile. In the case of the images above of a horse pancreatic lipase, the catalytic triad is comprised of <scene name='Lipase/Catalytic_triad/4'>Ser 152, Asp 176 and His 263. </scene><ref>PMID:8182745</ref> | ||
