4grt: Difference between revisions

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[[Image:4grt.~~gif~~|left|200px]]<br />

[[Image:4grt.jpg|left|200px]]<br /><applet load="4grt" size="450" color="white" frame="true" align="right" spinBox="true"

<applet load="4grt" size="450" color="white" frame="true" align="right" spinBox="true"

caption="4grt, resolution 2.80Å" />

'''HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, MIXED DISULFIDE BETWEEN TRYPANOTHIONE AND THE ENZYME'''<br />

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==Disease==

Known ~~disease~~ associated with this structure: Hemolytic anemia due to glutathione reductase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138300 138300]]

Known diseases associated with this structure: Hemolytic anemia due to glutathione reductase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138300 138300]], Mental retardation, autosomal recessive, 6 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138244 138244]]

==About this Structure==

4GRT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with FAD and GCG as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_1.8.1.7 Transferred entry: 1.8.1.7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.4.2 1.6.4.2] ~~Structure known Active~~ Sites: S1 and TS3. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=4GRT OCA].

4GRT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with FAD and GCG as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_1.8.1.7 Transferred entry: 1.8.1.7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.4.2 1.6.4.2] Known structural/functional Sites: <scene name='pdbsite=S1:The Active Site HIS (HIS 467) Is From The Other Subunit'>S1</scene> and <scene name='pdbsite=TS3:Trypanothione Forms A Mixed Disulfide Between Sg1 Ts3 17 ...'>TS3</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=4GRT OCA].

==Reference==

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[[Category: oxidoreductase]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 23~~:50:42 2007''

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 20:44:07 2007''

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@@ Line 1: / Line 1: @@
-[[Image:4grt.gif|left|200px]]<br />
+[[Image:4grt.jpg|left|200px]]<br /><applet load="4grt" size="450" color="white" frame="true" align="right" spinBox="true"
-<applet load="4grt" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="4grt, resolution 2.80&Aring;" />
 '''HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, MIXED DISULFIDE BETWEEN TRYPANOTHIONE AND THE ENZYME'''<br />
@@ Line 8: / Line 7: @@
 ==Disease==
-Known disease associated with this structure: Hemolytic anemia due to glutathione reductase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138300 138300]]
+Known diseases associated with this structure: Hemolytic anemia due to glutathione reductase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138300 138300]], Mental retardation, autosomal recessive, 6 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138244 138244]]
 ==About this Structure==
-GRT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with FAD and GCG as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_1.8.1.7 Transferred entry: 1.8.1.7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.4.2 1.6.4.2] Structure known Active Sites: S1 and TS3. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=4GRT OCA].
+GRT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with FAD and GCG as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_1.8.1.7 Transferred entry: 1.8.1.7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.4.2 1.6.4.2] Known structural/functional Sites: <scene name='pdbsite=S1:The Active Site HIS (HIS 467) Is From The Other Subunit'>S1</scene> and <scene name='pdbsite=TS3:Trypanothione Forms A Mixed Disulfide Between Sg1 Ts3 17 ...'>TS3</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=4GRT OCA].
 ==Reference==
@@ Line 29: / Line 28: @@
 [[Category: oxidoreductase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:50:42 2007''
+''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 20:44:07 2007''