1uwm: Difference between revisions
New page: left|200px<br /> <applet load="1uwm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uwm, resolution 2.00Å" /> '''REDUCED FERREDOXIN ... |
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==About this Structure== | ==About this Structure== | ||
1UWM is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus]] with FES as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UWM OCA]]. | 1UWM is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus]] with FES as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UWM OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: metal-binding]] | [[Category: metal-binding]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:58:30 2007'' | ||
Revision as of 08:53, 30 October 2007
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REDUCED FERREDOXIN 6 FROM RHODOBACTER CAPSULATUS
Overview
FdVI from Rhodobacter capsulatus is structurally related to a group of, [2Fe-2S] ferredoxins involved in iron-sulfur cluster biosynthesis., Comparative genomics suggested that FdVI and orthologs found in, alpha-Proteobacteria are involved in this process. Here, the crystal, structure of FdVI has been determined for both the oxidized and the, reduced protein. The [2Fe-2S] cluster lies 6 A below the protein surface, in a hydrophobic pocket without access to the solvent. This particular, cluster environment might explain why the FdVI midpoint redox potential, (-306 mV at pH 8.0) did not show temperature or ionic strength dependence., Besides the four cysteines that bind the cluster, FdVI features an extra, cysteine which is located close to the S1 atom of the cluster and is, oriented in a ... [(full description)]
About this Structure
1UWM is a [Single protein] structure of sequence from [Rhodobacter capsulatus] with FES as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of a [2Fe-2S] ferredoxin from Rhodobacter capsulatus likely involved in Fe-S cluster biogenesis and conformational changes observed upon reduction., Sainz G, Jakoncic J, Sieker LC, Stojanoff V, Sanishvili N, Asso M, Bertrand P, Armengaud J, Jouanneau Y, J Biol Inorg Chem. 2006 Mar;11(2):235-46. Epub 2006 Jan 10. PMID:16402206
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