SUMO: Difference between revisions
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New page: left|200px|thumb|Crystal Structure of human SUMO-2 protein, [[1wm2]] {{STRUCTURE_1wm2| PDB=1wm2 | SIZE=300| SCENE= |right|CAPTION=Human SUMO-2 protein, 1wm2 }} |
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[[Image:1wm2.png|left|200px|thumb|Crystal Structure of human SUMO-2 protein, [[1wm2]]]] | [[Image:1wm2.png|left|200px|thumb|Crystal Structure of human SUMO-2 protein, [[1wm2]]]] | ||
{{STRUCTURE_1wm2| PDB=1wm2 | SIZE=300| SCENE= |right|CAPTION=Human SUMO-2 protein, [[1wm2]] }} | {{STRUCTURE_1wm2| PDB=1wm2 | SIZE=300| SCENE=SUMO/Cv/1 |right|CAPTION=Human SUMO-2 protein, [[1wm2]] }} | ||
[[SUMO]] is a small ubiquitin-like modifier which covalently attaches to cellular proteins to modify their function. SUMO is similar in structure but not in sequence to ubiquitin. In several organisms SUMO is called SMT3. The SUMO-conjugating enzyme is called UBC9. The sentrin specific protease (SEPN) cleaves the C-terminal peptide from SUMO which then can bind to E1. The images at the left and at the right correspond to one representative SUMO, ''i.e.'' the crystal structure of human SUMO-2 protein ([[1wm2]]). | |||
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== 3D Structures of SUMO == | |||
=== SUMO === | |||
[[2k8h]] – SUMO – NMR – ''Trypanosoma brucei''<br /> | |||
[[1u4a]] – hSUMO-3 (mutant) – NMR – human<br /> | |||
[[1wm2]], [[1wm3]] – hSUMO-2<br /> | |||
=== SUMO+ubiquitin-like SUMO-conjugating enzyme === | |||
[[2vrr]], [[2uyz]] – mSUMO-1+UBC9<br /> | |||
[[2pe6]] - hSUMO-1+UBC9<br /> | |||
=== SUMO+sentrin specific protease === | |||
[[2io0]] – pre-hSUMO-2+SEPN2<br /> | |||
[[2io1]] - pre-hSUMO-3+SEPN2<br /> | |||
[[2g4d]] - hSUMO-1+SEPN1<br /> | |||
[[2iy1]] - hSUMO-1+SEPN1 (mutant)<br /> | |||
[[2iyd]], [[2ckh]] - hSUMO-2+SEPN1<br /> | |||
[[1tgz]] - hSUMO-1+SEPN2<br /> | |||
[[2io3]] - pre-hSUMO-2+SEPN2 (mutant)+RAN GTPase-activating enzyme (mutant)<br /> | |||
[[2iy0]] - hSUMO-1+SEPN1 (mutant)+RAN GTPase-activating enzyme <br /> | |||
=== SUMO+other proteins === | |||
[[2asq]] – hSUMO-1+SUMO-binding motif in PIASX<br /> | |||
[[3kyc]], [[3kyd]] – hSUMO+SUMO-activating enzyme <br /> | |||
[[2rpq]] – hSUMO-3+activating transcription factor <br /> | |||
=== SUMO+ubiquitin-conjugating enzyme === | |||
[[1z5s]] - hSUMO-1+E2+ RAN GTPase-activating enzyme<br /> | |||
[[2bf8]] - SUMO-1+E2 - bovine<br /> | |||
=== SMT3 === | |||
[[2k1f]] – SMT3 – Fruit fly<br /> | |||
[[2eke]] – ySMT3+UBC9 – yeast<br /> | |||
[[1euv]] – ySMT3+ULP1 protease<br /> | |||
