RNA Interference: Difference between revisions
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[[Image:500px-ShRNA Lentivirus.png|300px|left|thumb| Schematic of RNAi Interference in Mammalian Cells]] | |||
{{Structure | {{Structure | ||
|PDB= 3dlh |SIZE=300|SCENE=RNA_Interference/3dlh/2|CAPTION= guide-strand-containing Argonaute protein silencing complex ([[3dlh]]), resolution 3.00Å (<scene name='RNA_Interference/3dlh/2'>initial scene</scene>) | |PDB= 3dlh |SIZE=300|SCENE=RNA_Interference/3dlh/2|CAPTION= guide-strand-containing Argonaute protein silencing complex ([[3dlh]]), resolution 3.00Å (<scene name='RNA_Interference/3dlh/2'>initial scene</scene>) | ||
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[[RNA Interference]] (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded [[RNA]] is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand. | [[RNA Interference]] (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded [[RNA]] is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand. | ||
{{Structure | {{Structure | ||
