Fibrinogen: Difference between revisions

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<applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/Starting_scene/1" caption= 'Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, [[3hus]]' />
<applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/Starting_scene/1" caption= 'Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, [[3hus]]' />


'''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing Knobs A & B to form fibrin. <ref>PMID:16689770</ref> It is this fibrin that is linked to clotting factors like factor XIII which form clots to prevent excessive bleeding from wounds sustained. <ref>PMID:18673233</ref>
'''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing knobs A and B to form fibrin. <ref>PMID:16689770</ref> It is this fibrin that forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. <ref>PMID:18673233</ref>


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==3D Structure of Fibrinogen==
==3D Structure of Fibrinogen==


Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (<scene name='Fibrinogen/Fba/1'>Fba</scene>, <scene name='Fibrinogen/Fbb/1'>Fbb</scene>, <scene name='Fibrinogen/Fbg/1'>Fbg</scene> ) .   
Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (<scene name='Fibrinogen/Fba/1'>Fba</scene>, <scene name='Fibrinogen/Fbb/1'>Fbb</scene>, <scene name='Fibrinogen/Fbg/1'>Fbg</scene>).   


===Fibrinogen alpha+beta+gamma chains===
===Fibrinogen alpha+beta+gamma chains===


[[3hus]], [[3h32]], [[3e1i]], [[3bvh]], [[2hlo]], [[2hod]], [[2hpc]], [[2oyh]], [[2oyi]], [[2h43]], [[2ffd]], [[1re3]], [[1rf1]], [[1n86]], [[1ltj]] – hFba+hFbb+hFbg+peptide ligand – human <br />
==== Human ====
[[3ghg]], [[2q9i]], [[2z4e]] - hFba+hFbb+hFbg+knob A & B<br />
hFba + hFbb + hFbg:
[[2a45]] - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor<br />
[[1re4]], [[1rf0]], [[1n8e]], [[1lt9]]
[[1re4]], [[1rf0]], [[1n8e]], [[1lt9]] - hFba+hFbb+hFbg<br />
<br />
[[1jy3]], [[1deq]] – cFba+cFbb+cFbg - cow<br />
hFba + hFbb + hFbg + knobs A & B:
[[1n73]], [[1lwu]] - Fba+Fbb+Fbg+peptide ligand – Sea lamprey<br />
[[3ghg]], [[2q9i]], [[2z4e]]
[[1m1j]] - heFba+heFbb+heFbg+peptide ligand – hen<br />
<br />
[[1ei3]] - heFba+heFbb+heFbg<br />
hFba + hFbb + hFbg + peptide ligand:
[[3hus]], [[3h32]], [[3e1i]], [[3bvh]], [[2hlo]], [[2hod]], [[2hpc]], [[2oyh]], [[2oyi]], [[2h43]], [[2ffd]], [[1re3]], [[1rf1]], [[1n86]], [[1ltj]]  
<br />
hFba + hFbb + hFbg + thrombin + PPACK thrombin inhibitor:
[[2a45]]  
==== Cow ====
cFba + cFbb + cFbg:
[[1jy3]], [[1deq]]
==== Sea lamprey ====
Fba + Fbb + Fbg + peptide ligand:
[[1n73]], [[1lwu]]  
==== Hen ====
heFba + heFbb + heFbg:
[[1ei3]]
<br />
heFba + heFbb + heFbg + peptide ligand:
[[1m1j]]


===Fibrinogen alpha chain===
===Fibrinogen alpha chain===


[[1fzd]] – hFba EC domain<br />
cFba: [[2baf]]<br />
[[2jor]] – cFba – NMR<br />
cFba – NMR: [[2jor]]<br />
[[2baf]] – cFba<br />
hFba EC domain: [[1fzd]] <br />


===Fibrinogen beta chain===
===Fibrinogen beta chain===


[[1fzf]], [[1fzg]] – hFb fragment double-D +peptide ligand<br />
hFb fragment D: [[1fze]], [[1fza]], [[1fzb]]<br />
[[1fze]], [[1fza]], [[1fzb]] – hFb fragment D<br />
hFb fragment double-D + peptide ligand: [[1fzf]], [[1fzg]]<br />


===Fibrinogen gamma chain===
===Fibrinogen gamma chain===


[[2vr3]] – hFbg+SaClumping Factor A – Staphylococcus aureus<br />
hFbg: [[1fic]], [[1fid]] <br />
[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains<br />
hFbg + Ca: [[1fib]]<br />
[[2fib]], [[3fib]] - hFbg+peptide ligand<br />
hFbg + peptide ligand: [[2fib]], [[3fib]] <br />
[[1fib]] – hFbg+Ca<br />
hFbg + SaClumping Factor A – ''Staphylococcus aureus'': [[2vr3]]<br />
[[1fic]], [[1fid]] - hFbg<br />
hFbg + Integrin alpha IIB + Integrin beta-3 + Monoclonal antibody heavy and light chains: [[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] <br />


==References==
==References==
<references />
<references />
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