B-RAF with PLX4032: Difference between revisions
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==B-RAF with PLX4032== | ==B-RAF with PLX4032== | ||
PLX4032 is a newly synthesized drug that is being used to treat malignant | PLX4032 is a newly synthesized drug that is being used to treat malignant melanoma with a specific mutation. The mutation is B-RAF^(V600E). This drug is highly selective for this mutation and will not bind to wild type B-RAF. | ||
Revision as of 17:34, 30 September 2010
B-RAF with PLX4032
PLX4032 is a newly synthesized drug that is being used to treat malignant melanoma with a specific mutation. The mutation is B-RAF^(V600E). This drug is highly selective for this mutation and will not bind to wild type B-RAF.
PLX 4032
Wild-Type B-RAF
V600E Mutation
PLX4032 Sulfonamide N
H-Bond Interaction Asp594 and PLX4032
DFG in
DFG out
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