B-RAF with PLX4032: Difference between revisions
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<applet load='3og7' size='700' color='white' frame='true' align='right' caption='testcaption' /> | |||
<scene name='B-RAF_with_PLX4032/Plx_4032_only/1'>PLX 4032</scene><br> | <scene name='B-RAF_with_PLX4032/Plx_4032_only/1'>PLX 4032</scene><br> | ||
<scene name='B-RAF_with_PLX4032/Atp/1'>ATP</scene><br> | <scene name='B-RAF_with_PLX4032/Atp/1'>ATP</scene><br> | ||
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<scene name='B-RAF_with_PLX4032/Confirmation_change_dfg-in/1'>Confirmation Change DFG-In</scene> <br> | <scene name='B-RAF_with_PLX4032/Confirmation_change_dfg-in/1'>Confirmation Change DFG-In</scene> <br> | ||
<scene name='B-RAF_with_PLX4032/Confirmation_change_dfg-out/1'>Confirmation Change DFG-Out</scene> | <scene name='B-RAF_with_PLX4032/Confirmation_change_dfg-out/1'>Confirmation Change DFG-Out</scene> | ||
Revision as of 18:14, 7 October 2010
B-RAF with PLX4032
PLX4032 is a newly synthesized drug that is being used to treat malignant melanoma with a specific mutation. The mutation is B-RAF^(V600E). This drug is highly selective for this mutation and will not bind to wild type B-RAF.
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PLX 4032
ATP
Wild-Type B-RAF
V600E Mutation
PLX4032 Sulfonamide N
H-Bond Interaction Asp594 and PLX4032
DFG in
DFG out
Superposition
Confirmation Change DFG-In
Confirmation Change DFG-Out
