Cathepsin: Difference between revisions
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[[Image:1pbh.png|left|200px|thumb|Crystal structure wild-type human procathepsin B, [[1pbh]]]] | [[Image:1pbh.png|left|200px|thumb|Crystal structure wild-type human procathepsin B, [[1pbh]]]] | ||
{{STRUCTURE_1pbh| PDB=1pbh | SIZE=300| SCENE= |right|CAPTION=human procathepsin B, [[1pbh]] }} | {{STRUCTURE_1pbh| PDB=1pbh | SIZE=300| SCENE=Cathepsin/Cv/1 |right|CAPTION=human procathepsin B, [[1pbh]] }} | ||
[[Cathepsin]] (CTS) is a protease which becomes activated at low pH. It is found in lysosomes. Members of the CTS group are denoted as CTSA, CTSB etc and cleave proteins at different peptide bonds. The CTSs are expressed as an inactive precursor pro-CTS (PCTS) which become active when a long residue prosegment is cleaved off producing the mature CTS (MCTS). The images at the left and at the right correspond to one representative Cathepsin, ''i.e.'' the crystal structure of wild-type human procathepsin B ([[1pbh]]). | [[Cathepsin]] (CTS) is a protease which becomes activated at low pH. It is found in lysosomes. Members of the CTS group are denoted as CTSA, CTSB etc and cleave proteins at different peptide bonds. The CTSs are expressed as an inactive precursor pro-CTS (PCTS) which become active when a long residue prosegment is cleaved off producing the mature CTS (MCTS). The images at the left and at the right correspond to one representative Cathepsin, ''i.e.'' the crystal structure of wild-type human procathepsin B ([[1pbh]]). | ||
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[[1pbh]], [[2pbh]], [[3pbh]] – hPCTSB - human | [[1pbh]], [[2pbh]], [[3pbh]] – hPCTSB - human<br /> | ||
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[[3hhi]] – TbCTSB (mutant) residues 23-340+CA074 – Trypanosoma brucei | [[3hhi]] – TbCTSB (mutant) residues 23-340+CA074 – ''Trypanosoma brucei''<br /> | ||
[[3k9m]] – hMCTSB+stefin A | [[3k9m]] – hMCTSB+stefin A<br /> | ||
[[2ipp]], [[1huc]] – hMCTSB | [[2ipp]], [[1huc]] – hMCTSB<br /> | ||
[[3cbj]], [[3cbk]] – hMCTSB (mutant)+chagasin | [[3cbj]], [[3cbk]] – hMCTSB (mutant)+chagasin<br /> | ||
[[2dc6]], [[2dc7]], [[2dc8]], [[2dc9]], [[2dca]], [[2dcb]], [[2dcc]], [[2dcd]] – bMCTSB+inhibitor – bovine | [[2dc6]], [[2dc7]], [[2dc8]], [[2dc9]], [[2dca]], [[2dcb]], [[2dcc]], [[2dcd]] – bMCTSB+inhibitor – bovine | ||
[[1sp4]], [[1csb]] – bMCTSB+epoxysuccinyl inhibitor | [[1sp4]], [[1csb]] – bMCTSB+epoxysuccinyl inhibitor<br /> | ||
[[1ito]], [[1qdq]] – bMCTSB +inhibitor | [[1ito]], [[1qdq]] – bMCTSB +inhibitor<br /> | ||
[[1gmy]] - bMCTSB +dipeptidyl nitrile | [[1gmy]] - bMCTSB +dipeptidyl nitrile<br /> | ||
[[1the]] – rMCTSB (mutant)+butanone inhibitor – rat | [[1the]] – rMCTSB (mutant)+butanone inhibitor – rat<br /> | ||
[[1cpj]] - rMCTSB (mutant) | [[1cpj]] - rMCTSB (mutant)<br /> | ||
[[1cte]] - rMCTSB+pyrimidine inhibitor | [[1cte]] - rMCTSB+pyrimidine inhibitor<br /> | ||
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[[2djf]], [[2djg]] – hMCTSC +Gly-Phe-CHN2 | [[2djf]], [[2djg]] – hMCTSC +Gly-Phe-CHN2<br /> | ||
[[1jqp]] – rMCTSC | [[1jqp]] – rMCTSC<br /> | ||
[[1k3b]] – hMCTSC | [[1k3b]] – hMCTSC <br /> | ||
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[[1lyw]], [[1lya]] – hMCTSD | [[1lyw]], [[1lya]] – hMCTSD <br /> | ||
[[1lyb]] - hMCTSD+pepstatin | [[1lyb]] - hMCTSD+pepstatin<br /> | ||
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[[1tzs]] – hMCTSE+activation peptide from CTSE | [[1tzs]] – hMCTSE+activation peptide from CTSE<br /> | ||
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[[1m6d]] – hMCTSF+piperidine inhibitor | [[1m6d]] – hMCTSF+piperidine inhibitor<br /> | ||
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[[1kyn]] – hMCTSG +naphthalene inhibitor | [[1kyn]] – hMCTSG +naphthalene inhibitor<br /> | ||
[[1au8]], [[1cgh]] - hMCTSG +phosphonate inhibitor | [[1au8]], [[1cgh]] - hMCTSG +phosphonate inhibitor<br /> | ||
=== Cathepsin-H mature === | === Cathepsin-H mature === | ||
[[1nb]]3, [[1nb5]] – pMCTSH +stefin A – pig | [[1nb]]3, [[1nb5]] – pMCTSH +stefin A – pig<br /> | ||
[[8pch]] - pMCTSH | [[8pch]] - pMCTSH <br /> | ||
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[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]] – hMCTSK+ pyrimidine inhibitor | [[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]] – hMCTSK+ pyrimidine inhibitor<br /> | ||
[[3mpe]], [[3mpf]] – hMCTSK (mutant) + pyrimidine inhibitor | [[3mpe]], [[3mpf]] – hMCTSK (mutant) + pyrimidine inhibitor<br /> | ||
[[3h7d]] - hMCTSK (mutant) + chondroitin-4-sulfate | [[3h7d]] - hMCTSK (mutant) + chondroitin-4-sulfate<br /> | ||
[[3c9e]] - hMCTSK + chondroitin-4-sulfate | [[3c9e]] - hMCTSK + chondroitin-4-sulfate<br /> | ||
[[3kwb]] - hMCTSK (mutant)+dioxo-triazine | [[3kwb]] - hMCTSK (mutant)+dioxo-triazine<br /> | ||
[[3kw9]] - hMCTSK +triazine | [[3kw9]] - hMCTSK +triazine<br /> | ||
[[1yk8]] - hMCTSK + cyanamide inhibitor | [[1yk8]] - hMCTSK + cyanamide inhibitor<br /> | ||
[[1yt7]] - hMCTSK + ketoamide inhibitor | [[1yt7]] - hMCTSK + ketoamide inhibitor<br /> | ||
[[2aux]], [[2auz]] - hMCTSK + semicarbazone inhibitor | [[2aux]], [[2auz]] - hMCTSK + semicarbazone inhibitor<br /> | ||
[[1ayu]], [[1ayv]], [[1ayw]] - hMCTSK + carbohydrazide inhibitor | [[1ayu]], [[1ayv]], [[1ayw]] - hMCTSK + carbohydrazide inhibitor<br /> | ||
[[2bdl]], [[1yk7]], [[1tu6]], [[1au3]], [[1au4]] - hMCTSK + pyrrolidine inhibitor | [[2bdl]], [[1yk7]], [[1tu6]], [[1au3]], [[1au4]] - hMCTSK + pyrrolidine inhibitor<br /> | ||
[[1snk]] - hMCTSK + norleucine inhibitor | [[1snk]] - hMCTSK + norleucine inhibitor<br /> | ||
[[1nl6]], [[1nlj]] - hMCTSK+ azepanone inhibitor | [[1nl6]], [[1nlj]] - hMCTSK+ azepanone inhibitor<br /> | ||
[[1q6k]] - hMCTSK+carbamate inhibitor | [[1q6k]] - hMCTSK+carbamate inhibitor<br /> | ||
[[1au0]] - hMCTSK+ diacylaminoethyl ketone inhibitor | [[1au0]] - hMCTSK+ diacylaminoethyl ketone inhibitor<br /> | ||
[[1au2]] - hMCTSK+ propanone inhibitor | [[1au2]] - hMCTSK+ propanone inhibitor<br /> | ||
[[1atk]] – hMCTSK+guanidine inhibitor | [[1atk]] – hMCTSK+guanidine inhibitor<br /> | ||
[[1vsn]] - hMCTSK+ inhibitor | [[1vsn]] - hMCTSK+ inhibitor<br /> | ||
[[2ato]] – hMCTSK+myocrisin | [[2ato]] – hMCTSK+myocrisin<br /> | ||
[[1u9v]], [[1u9x]], [[1mem]] – hMCTSK+piperazine inhibitor | [[1u9v]], [[1u9x]], [[1mem]] – hMCTSK+piperazine inhibitor<br /> | ||
[[1u9w]] - hMCTSK+imidazole inhibitor | [[1u9w]] - hMCTSK+imidazole inhibitor<br /> | ||
[[2ftd]] – MCTSK+azepan inhibitor – Macaca mulatta | [[2ftd]] – MCTSK+azepan inhibitor – ''Macaca mulatta''<br /> | ||
[[2f7d]] – MCTSK (mutant)+nitrile inhibitor - rabbit | [[2f7d]] – MCTSK (mutant)+nitrile inhibitor - rabbit<br /> | ||
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[[3f75]] – MCTSL +CTSL propeptide – Toxoplasma gondii | [[3f75]] – MCTSL +CTSL propeptide – ''Toxoplasma gondii''<br /> | ||
[[2p86]] – TbMCTSL +K11002 | [[2p86]] – TbMCTSL +K11002<br /> | ||
[[2nqd]] - CTSL residues 1-220 (mutant)+chagasin – Trypanosoma cruzi | [[2nqd]] - CTSL residues 1-220 (mutant)+chagasin – ''Trypanosoma cruzi''<br /> | ||
[[1mhw]] – hMCTSL +tripeptide | [[1mhw]] – hMCTSL +tripeptide<br /> | ||
[[1icf]] – hMCTSL +MHC class II fragment | [[1icf]] – hMCTSL +MHC class II fragment<br /> | ||
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[[2o6x]] – hPCTSL1 (mutant) – Fasciola hepatica | [[2o6x]] – hPCTSL1 (mutant) – ''Fasciola hepatica''<br /> | ||
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[[3iv2]] – hMCTSL1 (mutant) | [[3iv2]] – hMCTSL1 (mutant) <br /> | ||
[[3k24]] - hMCTSL1 (mutant) +tripeptide | [[3k24]] - hMCTSL1 (mutant) +tripeptide<br /> | ||
[[3bc3]] - hMCTSL1 +inhibitor | [[3bc3]] - hMCTSL1 +inhibitor<br /> | ||
[[3h89]], [[3h8b]], [[3h8c]] - hMCTSL1 (mutant) + retro-binding inhibitor | [[3h89]], [[3h8b]], [[3h8c]] - hMCTSL1 (mutant) + retro-binding inhibitor<br /> | ||
[[3hwn]], [[3hha]] – hMCTSL1+pyrazole inhibitor | [[3hwn]], [[3hha]] – hMCTSL1+pyrazole inhibitor<br /> | ||
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[[3h6s]] – hMCTSL2+clitocypin | [[3h6s]] – hMCTSL2+clitocypin<br /> | ||
[[1fh0]] – hMCTSL2 (mutant) +vinyl sulfone inhibitor | [[1fh0]] – hMCTSL2 (mutant) +vinyl sulfone inhibitor<br /> | ||
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[[2c0y]] – hPCTSS (mutant) | [[2c0y]] – hPCTSS (mutant)<br /> | ||
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[[3n3g]] - hMCTSS+ pyrimidine inhibitor | [[3n3g]] - hMCTSS+ pyrimidine inhibitor<br /> | ||
[[3kwn]] – hMCTSS (mutant)+ thioether acetamide | [[3kwn]] – hMCTSS (mutant)+ thioether acetamide<br /> | ||
[[3iej]] - hMCTSS (mutant)+pyrazole inhibitor | [[3iej]] - hMCTSS (mutant)+pyrazole inhibitor<br /> | ||
[[2h7j]], [[2hxz]]- hMCTSS+triazole inhibitor | [[2h7j]], [[2hxz]]- hMCTSS+triazole inhibitor<br /> | ||
[[2r9m]], [[2r9n]], [[2r9o]] – hMCTSS+piperidine inhibitor | [[2r9m]], [[2r9n]], [[2r9o]] – hMCTSS+piperidine inhibitor<br /> | ||
[[2op3]], [[2hhn]], [[2g7y]], [[2hh5]], [[2f1g]] – hMCTSS+aryl inhibitor | [[2op3]], [[2hhn]], [[2g7y]], [[2hh5]], [[2f1g]] – hMCTSS+aryl inhibitor<br /> | ||
[[2fud]], [[2fra]], [[2frq]], [[2ft2]], [[1npz]], [[1nqc]] – hMCTSS+inhibitor | [[2fud]], [[2fra]], [[2frq]], [[2ft2]], [[1npz]], [[1nqc]] – hMCTSS+inhibitor<br /> | ||
[[2fye]], [[2g6d]] – hMCTSS (mutant)+inhibitor | [[2fye]], [[2g6d]] – hMCTSS (mutant)+inhibitor<br /> | ||
[[2fq9]], [[1ms6]] – hMCTSS +nitrile inhibitor | [[2fq9]], [[1ms6]] – hMCTSS +nitrile inhibitor<br /> | ||
[[1glo]] - hMCTSS (mutant) | [[1glo]] - hMCTSS (mutant)<br /> | ||
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[[1deu]] - hPCTSX | [[1deu]] - hPCTSX<br /> | ||
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[[1ef7]] – hMCTSX | [[1ef7]] – hMCTSX<br /> | ||
