Cluster of Differentiation CD38: Difference between revisions
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New page: left|200px|thumb|Crystal Structure of bovine Cluster of Differentiation 38 (CD38) [[2zm6]] {{STRUCTURE_3gc6| PDB=3gc6 | SIZE=300| SCENE= |right|CAPTION=Cluster of Diff... |
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[[Image: | [[Image:3gc6a.jpg|left|200px|thumb|Crystal Structure of bovine Cluster of Differentiation 38 (CD38) [[3gc6]]]] | ||
{{STRUCTURE_3gc6| PDB=3gc6 | SIZE=300| SCENE= |right|CAPTION=Cluster of Differentiation 38 (CD38) [[3gc6]] }} | {{STRUCTURE_3gc6| PDB=3gc6 | SIZE=300| SCENE=Cluster_of_Differentiation_38/Cv/1 |right|CAPTION=Cluster of Differentiation 38 (CD38) [[3gc6]] }} | ||
[[Cluster of Differentiation 38]] (CD38) catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca++ signaling. The images at the left and at the right correspond to one representative CD38, ''i.e.'' the crystal structure of bovine Cluster of Differentiation 38 ([[3gc6]]). | |||
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== 3D Structures of Cluster of Differentiation 38 == | |||
=== CD38 === | |||
[[3gc6]] – bCD38 - bovine<br /> | |||
[[3gh3]], [[3ghh]] – bCD38 residues 32-278<br /> | |||
[[2eg9]] - CD38 enzymatic domain (mutant) – mouse<br /> | |||
[[2ef1]] - hCD38 enzymatic domain – human<br /> | |||
[[1yh3]] - hCD38 enzymatic domain (mutant)<br /> | |||
[[1zvm]] - hCD38 (mutant)<br /> | |||
=== CD38+ligand === | |||
[[3i9m]], [[3i9n]] – hCD38 enzymatic domain+ADPR analog<br /> | |||
[[3f6y]] – hCD38 enzymatic domain+Ca++<br /> | |||
[[3dzf]] - hCD38 enzymatic domain+intermediate<br /> | |||
[[3dzg]] - hCD38 enzymatic domain (mutant)+intermediate/nicotinamide complex<br /> | |||
[[3dzh]] - hCD38 enzymatic domain (mutant)+GTP<br /> | |||
[[3dzi]] - hCD38 enzymatic domain (mutant)+intermediate/GTP complex<br /> | |||
[[3dzj]], [[3dzk]] - hCD38 enzymatic domain (mutant)+NMN complex<br /> | |||
[[2pgj]], [[2pgl]] - hCD38 enzymatic domain (mutant)+substrate analog<br /> | |||
[[2o3t]] - hCD38 enzymatic domain (mutant)+cGDPR<br /> | |||
[[2o3u]] - hCD38 enzymatic domain (mutant)+NGD <br /> | |||
[[2o3q]], [[2o3r]], [[2o3s]] - hCD38 enzymatic domain (mutant)+cADPR<br /> | |||
[[2i65]] – hCD38+NAD<br /> | |||
[[2i66]] - hCD38 (mutant)+GDP intermediate<br /> | |||
[[2i67]] - hCD38 (mutant)+ADPR<br /> | |||
[[2hct]] - hCD38 enzymatic domain (mutant)+NMN<br /> | |||
