1yhp: Difference between revisions
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'''Solution Structure of Ca2+-free DdCAD-1'''<br /> | '''Solution Structure of Ca2+-free DdCAD-1'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1YHP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http:// | 1YHP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YHP OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: nmr]] | [[Category: nmr]] | ||
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Revision as of 09:17, 23 January 2008
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Solution Structure of Ca2+-free DdCAD-1
Overview
DdCAD-1 is a novel Ca(2+)-dependent cell adhesion molecule that lacks a, hydrophobic signal peptide and a transmembrane domain. DdCAD-1 is, expressed by the social amoeba Dictyostelium discoideum at the onset of, development. It is synthesized as a soluble protein and then transported, to the plasma membrane by contractile vacuoles. Here we describe the novel, features of the solution structures of Ca(2+)-free and Ca(2+)-bound, monomeric DdCAD-1. DdCAD-1 contains two beta-sandwich domains, belonging, to the betagamma-crystallin and immunoglobulin fold classes, respectively., Whereas the N-terminal domain has a major role in homophilic binding, the, C-terminal domain tethers the protein to the cell membrane. From, structural and mutational analyses, we propose a model for the, Ca(2+)-bound DdCAD-1 dimer as a basis for understanding DdCAD-1-mediated, cell-cell adhesion at the molecular level. Our results provide new, insights into Ca(2+)-dependent mechanisms for cell-cell adhesion.
About this Structure
1YHP is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.
Reference
Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion., Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D, Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:17057715
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