User:Eran Hodis/Sandbox7: Difference between revisions
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Eran Hodis (talk | contribs) New page: 350px|left|thumb| Human HMG-CoA Reductase Catalytic Domain, [[1dqa]] {{STRUCTURE_1dq8| right| PDB=1dq8 | SCENE=HMG-CoA_Reductase/1dq8_starting_scene/1 |CAPTION=... |
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[[Image:1dqa opening.png|350px|left|thumb| Human HMG-CoA Reductase Catalytic Domain, [[1dqa]]]] | [[Image:1dqa opening.png|350px|left|thumb| Human HMG-CoA Reductase Catalytic Domain, [[1dqa]]]] | ||
{{STRUCTURE_1dq8| right| PDB=1dq8 | SCENE=HMG-CoA_Reductase/1dq8_starting_scene/1 |CAPTION= Crystal Structure of Human HMG-CoA Reductase Catalytic Domain, [[1dq8]] }} | {{STRUCTURE_1dq8| right| PDB=1dq8 | SCENE=HMG-CoA_Reductase/1dq8_starting_scene/1 |CAPTION= Crystal Structure of Human HMG-CoA Reductase Catalytic Domain, [[1dq8]] }} | ||
[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductasese''' or '''HMGR''') is the rate-controlling enzyme of the metabolic pathway responsible for [ | [[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductasese''' or '''HMGR''') is the rate-controlling enzyme of the metabolic pathway responsible for [[cholesterol]] and other isoprenoid biosynthesis, the [[mevalonate pathway]]. HMGR is a polytopic, transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman"/> It is the major target of the statins, a cholesterol lowering drug class and the best selling pharmaceutical drugs in the world. | ||
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