Sandbox 50: Difference between revisions
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In order for trypsinogen to be converted to trypsin, a pro-peptide must be cleaved from trypsinogen. The image at the left shows which sequence is removed from trypsinogen, and the active site of trypsin becomes accessible for its protein substrate. | In order for trypsinogen to be converted to trypsin, a pro-peptide must be cleaved from trypsinogen. The image at the left shows which sequence is removed from trypsinogen, and the active site of trypsin becomes accessible for its protein substrate. | ||
The rate of conversion of trypsinogen to trypsin can be enhanced with calcium ions. Both trypsinogen and trypsin contain an | The rate of conversion of trypsinogen to trypsin can be enhanced with calcium ions. Both trypsinogen and trypsin contain an autolysis loop. This autolysis loop is comprised of residues 143-151, and contains a high affinity calcium ion binding site that is required for stability. When the calcium ion is not present, autolysis (self-digestion) will occur. | ||
[[Image:Trypsinogen.gif |thumb]] | [[Image:Trypsinogen.gif |thumb]] | ||
==Trypsin Inhibition== | ==Trypsin Inhibition== | ||
