Sandbox 30: Difference between revisions

There are four <scene name='Sandbox_30/So4_ligands/1'>ligands</scene> present in 1QLQ, which are stabilized mostly by hydrogen bonding.  For example, <scene name='Sandbox_30/So4_ligand_62_a/1'>SO4 62 A</scene> is stabilized by hydrogen bonds using the oxygens on SO4. There is a image to the right showing the bonding interaction.  

Trypsin's zymogen form is called trypsinogen, and can actually activate itself.  Zymogens require a biochemical change to activate.  Only an activated form of trypsin can activate the trypsinogen, and this initial activation is carried out by enteropeptidase, which is a serine protease as well.  Because activated forms of trypsin can activate others, trypsin is said to be autocatalytic<ref>Voet, Donald et al. Fundamentals of Biochemistry - Life at the Molecular Level. 3rd ed. John Wiley & Sons, Inc. 2008</ref>. In addition to activating itself, it can also activate [http://www.proteopedia.org/wiki/index.php/Chymotrypsin chymotrypsin] and [http://www.proteopedia.org/wiki/index.php/Elastase elastase].