Simvastatin: Difference between revisions

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===Effectiveness and Side Effects===

====Effectiveness====

At the 20mg dose, Simvastatin reduces LDL concentration by 30-40%, in line with 5mg of Rosuvastatin ([[Crestor]]) and 10mg of Atorvastatin ([[Lipitor]]). Of particular note, at the 20mg dosage, Simvastatin had the most variable results, with patients experiencing drops in LDL ranging from 20%, well below the minimum of Crestor and Lipitor, to as high as 55%, as high as the maximum, 80mg dosage of Lipitor. At 80mg, Atorvastatin appears to be more effective at preventing coronary heart disease compared to 20mg Simvastatin, but considering the variation in dosage level, it is difficult to directly compare these results. <ref>PMID:11464446</ref><ref>PMID:20456733</ref>

====Side Effects====

~~Although all~~ of the ~~statins are generally considered safe, rosuvastatin had a higher reported adverse event rate than other statin clinical trials~~. Typical adverse events include muscle weakness, headache dizziness and slightly increased creatinine kinase (CK) levels (an indication of kidney and smooth muscle damage), although these are common to all the statins (with the exception of elevated CK levels which only occurs in [[Atorvastatin]], [[Rosuvastatin]], and Simvastatin)<ref>PMID:20456733</ref> ~~SEE~~ http://www.~~druginjuryattorneyblog~~.com/~~2010~~/03/~~fda_warns_patients_that_choles.html~~

The Statins are one of the safest drug classes to reach block buster status. Typical adverse events include muscle weakness, headache dizziness and slightly increased creatinine kinase (CK) levels (an indication of kidney and smooth muscle damage), although these are common to all the statins (with the exception of elevated CK levels which only occurs in [[Atorvastatin]], [[Rosuvastatin]], and Simvastatin)<ref>PMID:20456733</ref> In March, 2010, the FDA issued a warning about an increased rate of Rhabdomyolysis, a dangerous breakdown of muscle fiber, releasing [[myoglobin]] into the bloodstream, potentially resulting in severe kidney damage. Although these concerns are not enough to have patients cease use of Zocor, it is important for the public to be aware of the issue. <ref>http://www.reuters.com/article/idUSTRE62I3YW20100319</ref>

===Interesting Facts===

===The Jist===

===References===

Simvastatin: Difference between revisions

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@@ Line 90: / Line 90: @@
 ===Effectiveness and Side Effects===
 ====Effectiveness====
-<ref>PMID:20456733</ref>
+At the 20mg dose, Simvastatin reduces LDL concentration by 30-40%, in line with 5mg of Rosuvastatin ([[Crestor]]) and 10mg of Atorvastatin ([[Lipitor]]). Of particular note, at the 20mg dosage, Simvastatin had the most variable results, with patients experiencing drops in LDL ranging from 20%, well below the minimum of Crestor and Lipitor, to as high as 55%, as high as the maximum, 80mg dosage of Lipitor. At 80mg, Atorvastatin appears to be more effective at preventing coronary heart disease compared to 20mg Simvastatin, but considering the variation in dosage level, it is difficult to directly compare these results. <ref>PMID:11464446</ref><ref>PMID:20456733</ref>
 ====Side Effects====
-Although all of the statins are generally considered safe, rosuvastatin had a higher reported adverse event rate than other statin clinical trials. Typical adverse events include muscle weakness, headache dizziness and slightly increased creatinine kinase (CK) levels (an indication of kidney and smooth muscle damage), although these are common to all the statins (with the exception of elevated CK levels which only occurs in [[Atorvastatin]], [[Rosuvastatin]], and Simvastatin)<ref>PMID:20456733</ref>  SEE http://www.druginjuryattorneyblog.com/2010/03/fda_warns_patients_that_choles.html
+The Statins are one of the safest drug classes to reach block buster status. Typical adverse events include muscle weakness, headache dizziness and slightly increased creatinine kinase (CK) levels (an indication of kidney and smooth muscle damage), although these are common to all the statins (with the exception of elevated CK levels which only occurs in [[Atorvastatin]], [[Rosuvastatin]], and Simvastatin)<ref>PMID:20456733</ref> In March, 2010, the FDA issued a warning about an increased rate of Rhabdomyolysis, a dangerous breakdown of muscle fiber, releasing [[myoglobin]] into the bloodstream, potentially resulting in severe kidney damage. Although these concerns are not enough to have patients cease use of Zocor, it is important for the public to be aware of the issue. <ref>http://www.reuters.com/article/idUSTRE62I3YW20100319</ref>
 ===Interesting Facts===
 ===The Jist===
 ===References===