Pioglitazone: Difference between revisions

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<applet  load="" size="480" color="" frame="true"  spin="on" Scene ="User:David_Canner/Sandbox_crestor/Rosu/1" align="right" caption="Rosuvastatin, also known as Crestor"/>
===Better Known as: Actos===
===Better Known as: Actos===
* Marketed By: Takeda Pharmaceuticals<br />
* Marketed By: Takeda Pharmaceuticals<br />
Line 8: Line 7:
* Why You Should Care: It is the best selling drug to treat Diabetes and is the 10th best selling drug in the United States.  
* Why You Should Care: It is the best selling drug to treat Diabetes and is the 10th best selling drug in the United States.  
* The following is a list of Pharmacokinetic Parameters. See: [[Pharmaceutical Drugs]] for more information
* The following is a list of Pharmacokinetic Parameters. See: [[Pharmaceutical Drugs]] for more information
===Mechanism of Action===
===Pharmacokinetics===
{| class="wikitable" border="1" width="40%" style="text-align:center"
|-
!  colspan="6" align="center"| Glitazone Comparison
|-
! Parameter
! [[Pioglitazone]] (Actos)
! [[Rosiglitazone]] (Avandia)
|-
! [[Pharmaceutical_Drugs#Tmax|T<sub>max</sub>]] (hr)
!
!
|-
! [[Pharmaceutical_Drugs#Cmax|C<sub>max</sub>]] (ng/ml)
!
!
|-
! [[Pharmaceutical_Drugs#Bioavailability_.28F.29|Bioavailability]] (%)
!
!
|-
! [[Pharmaceutical_Drugs#Protein_Binding|Protein Binding]] (%)
! 99
! 99
|-
! [[Pharmaceutical_Drugs#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr)
! 3-7
! 3-4
|-
! [[Pharmaceutical_Drugs#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr)
!
!
|-
! [[Pharmaceutical_Drugs#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM)
!
!
|-
! Equivalent Dosage (mg)
!
!
|-
! Metabolism
! Hepatic <br/>(CYP2C8)
! Hepatic <br/>(CYP2C8)
|}
===Effectiveness and Side Effects===
====Effectiveness====
====Side Effects====
===Interesting Facts===
===The Jist===


===References===
===References===

Revision as of 08:50, 11 November 2010

Better Known as: Actos

  • Marketed By: Takeda Pharmaceuticals
  • Major Indication: Hypoglycemia & Type 2 Diabetes
  • Drug Class: PPAR-γ Activator - Thiazolidinedione (Glitazones)
  • Date of FDA Approval (Patent Expiration): 1999 (2011)
  • 2009 Sales: $2.4 Billion [1]
  • Why You Should Care: It is the best selling drug to treat Diabetes and is the 10th best selling drug in the United States.
  • The following is a list of Pharmacokinetic Parameters. See: Pharmaceutical Drugs for more information

References

  1. ↑ https://drugpatentwatch.com/ultimate/preview/tradename/index.php?query=ACTOS


Proteopedia Page Contributors and Editors (what is this?)

David Canner, Alexander Berchansky

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