AZT-resistant HIV-1 reverse transcriptase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
| Line 17: | Line 17: | ||
[[Reverse transcriptase]] is a heterodimer of two related <scene name='AZT-resistant_HIV-1_reverse_transcriptase/Subunits/1'>subunits</scene>: p66 and p51. The p66 subunit has 560 amino acid residues, while the p51 subunit has 440 amino acids. The larger subunit, p66, contains the active sites for both enzymatic activities (DNA polymerase and RNase H), while the smaller subunit, p51, has a structural role. | [[Reverse transcriptase]] is a heterodimer of two related <scene name='AZT-resistant_HIV-1_reverse_transcriptase/Subunits/1'>subunits</scene>: p66 and p51. The p66 subunit has 560 amino acid residues, while the p51 subunit has 440 amino acids. The larger subunit, p66, contains the active sites for both enzymatic activities (DNA polymerase and RNase H), while the smaller subunit, p51, has a structural role. | ||
Two distinct domains, polymerase and RNase H form the p66 subunit. The polymerase domain consists of four subdomains: | Two distinct domains, polymerase and RNase H form the p66 subunit. The polymerase domain consists of four subdomains: finger (residues 1-85 and 118-155), palm (residues 86-117 and 156-236), thumb (residues 237-318), and connection (residues 319-426). | ||
[[Image:RT finger.png]] | [[Image:RT finger.png]] | ||
Finger subdomain | |||
==Inhibition of Reverse Transcriptase Activity== | ==Inhibition of Reverse Transcriptase Activity== | ||
