Sandbox c33: Difference between revisions
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It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. | It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. | ||
Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 ( | Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (). | ||
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649 | Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649 | ||
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Copy and paste the following line where you want the scene link to appear (scroll down if needed) and edit the TextToBeDisplayed: | Copy and paste the following line where you want the scene link to appear (scroll down if needed) and edit the TextToBeDisplayed: | ||
<scene name='Sandbox_c33/Try_phenil/1'> | <scene name='Sandbox_c33/Try_phenil/1'>W84 and F330</scene> | ||
