Matrix Metalloproteinase 12: Difference between revisions
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== Introduction == | == Introduction == | ||
[[Matrix Metalloproteinase 12]] is a human protease. It belongs to the Matrix Metalloproteinase’s family (MMPs). Theses MMPs are secreted as inactive proproteins and then activated after a cleavage by extracellular proteinases. | |||
MMPs are sorted into 17 classes depending on their localization in the cell, and on their substrates. For instance, 2Oxu is a macrophage metalloelastane indexed in MMP12 subfamily. This hydrolysis involves two cofactors: <scene name='User:Julie_Frentzel/Sandbox_1/Zn/1'>zinc</scene> and <scene | MMPs are sorted into 17 classes depending on their localization in the cell, and on their substrates. For instance, 2Oxu is a macrophage metalloelastane indexed in MMP12 subfamily. This hydrolysis involves two cofactors: <scene name='User:Julie_Frentzel/Sandbox_1/Zn/1'>zinc</scene> and <scene | ||
name='User:Julie_Frentzel/Sandbox_1/Ca/1'>calcium</scene>. Zn2+ atoms are part of the enzyme whereas Ca2+ atoms are hydrogen bounded to the backbone of the protein. | name='User:Julie_Frentzel/Sandbox_1/Ca/1'>calcium</scene>. Zn2+ atoms are part of the enzyme whereas Ca2+ atoms are hydrogen bounded to the backbone of the protein. | ||
