Matrix Metalloproteinase 12: Difference between revisions
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[[Matrix Metalloproteinase 12]] is a human protease which is involved in tissue remodelling and cell signalling. The MMPs are secreted as inactive proproteins and then activated after a cleavage by extracellular proteinases. | [[Matrix Metalloproteinase 12]] is a human protease which is involved in tissue remodelling and cell signalling. The MMPs are secreted as inactive proproteins and then activated after a cleavage by extracellular proteinases. | ||
MMPs are sorted into 17 classes depending on their localization in the cell, and on their substrates. For instance, MMP12 is a macrophage metalloelastane coded by the MMP12 gene. | MMPs are sorted into 17 classes depending on their localization in the cell, and on their substrates. For instance, MMP12 is a macrophage metalloelastane coded by the MMP12 gene. | ||
In healthy cells, 2oxu is implied in tissue remodelling and cell signalling. Its role is to allow the migration of the macrophages in tissues by hydrolysing soluble and insoluble elastin of the extracellular matrix by involving two cofactors: <scene name=' | In healthy cells, 2oxu is implied in tissue remodelling and cell signalling. Its role is to allow the migration of the macrophages in tissues by hydrolysing soluble and insoluble elastin of the extracellular matrix by involving two cofactors: <scene name='Matrix_Metalloproteinase_12/Zn/1'>zinc</scene> and <scene | ||
name='User:Julie_Frentzel/Sandbox_1/Ca/1'>calcium</scene>. Zn2+ atoms are part of the enzyme whereas Ca2+ atoms are hydrogen bounded to the backbone of the protein. | name='User:Julie_Frentzel/Sandbox_1/Ca/1'>calcium</scene>. Zn2+ atoms are part of the enzyme whereas Ca2+ atoms are hydrogen bounded to the backbone of the protein. | ||
Because of its activity, this protein is also involved in metastasis and tumor development; that's why it is considered as an important target for drug therapies. | Because of its activity, this protein is also involved in metastasis and tumor development; that's why it is considered as an important target for drug therapies. | ||
