Matrix Metalloproteinase 12: Difference between revisions
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A proton of one of the three H2O moves to the <scene name=' | A proton of one of the three H2O moves to the <scene name='Matrix_Metalloproteinase_12/Zn/3'>Glu 219</scene> catalytic site's residue. | ||
It creates a hydroxyl group with a high nucleophilic character. | It creates a hydroxyl group with a high nucleophilic character. | ||
That leads to a nucleophilic attack by zinc-coordinated hydroxyl group, on one of the carbonyl group of the substrate (Gly206). | That leads to a nucleophilic attack by zinc-coordinated hydroxyl group, on one of the carbonyl group of the substrate (Gly206). | ||
