Tositumomab: Difference between revisions
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David Canner (talk | contribs) New page: ===Pharmacokinetics=== {| class="wikitable" border="1" width="52%" style="text-align:center" |- ! colspan="12" align="center"| Anti-CD20 Monoclonal Antibody [[Pharmaceutical_Drugs#Pharmac... |
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! Ibritumomab | ! Ibritumomab | ||
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! [[Pharmaceutical_Drugs#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM) | |||
! Tositumomab | ! Tositumomab | ||
! Ofatumumab | ! Ofatumumab | ||
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! Ibritumomab | ! Ibritumomab | ||
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! Dosage (mg) | |||
! Tositumomab | ! Tositumomab | ||
! Ofatumumab | ! Ofatumumab | ||
! Rituximab | ! Rituximab | ||
! Ibritumomab | ! Ibritumomab | ||
|- | |||
! Metabolism | |||
! Tositumomab | |||
! Ofatumumab | |||
! Rituximab | |||
! Ibritumomab | |||
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Revision as of 06:38, 6 December 2010
Pharmacokinetics
| Anti-CD20 Monoclonal Antibody Pharmacokinetics | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | Tositumomab | Ofatumumab | Rituximab | Ibritumomab | |||||||
| Tmax (hr) | Tositumomab | Ofatumumab | Rituximab | Ibritumomab | |||||||
| Cmax (ng/ml) | Tositumomab | Ofatumumab | Rituximab | Ibritumomab | |||||||
| Bioavailability (%) | Tositumomab | Ofatumumab | Rituximab | Ibritumomab | |||||||
| Protein Binding (%) | Tositumomab | Ofatumumab | Rituximab | Ibritumomab | |||||||
| T1/2 (hr) | Tositumomab | Ofatumumab | Rituximab | Ibritumomab | |||||||
| AUC (ng/ml/hr) | Tositumomab | Ofatumumab | Rituximab | Ibritumomab | |||||||
| Clearance (L/h) | Tositumomab | Ofatumumab | Rituximab | Ibritumomab | |||||||
| IC50 (nM) | Tositumomab | Ofatumumab | Rituximab | Ibritumomab | |||||||
| Dosage (mg) | Tositumomab | Ofatumumab | Rituximab | Ibritumomab | |||||||
| Metabolism | Tositumomab | Ofatumumab | Rituximab | Ibritumomab | |||||||
|}
