Aerolysin: Difference between revisions
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New page: left|200px|thumb|Crystal Structure of Proaerolysin [[1pre]] {{STRUCTURE_1pre| PDB=1pre | SIZE=300| SCENE= |right|CAPTION=Proaerolysin 1pre }} Aerolysin (Aer) ... |
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[[Image:1pre.png|left|200px|thumb|Crystal Structure of Proaerolysin [[1pre]]]] | [[Image:1pre.png|left|200px|thumb|Crystal Structure of Proaerolysin [[1pre]]]] | ||
{{STRUCTURE_1pre| PDB=1pre | SIZE=300| SCENE= |right|CAPTION=Proaerolysin [[1pre]] }} | {{STRUCTURE_1pre| PDB=1pre | SIZE=300| SCENE=Aerolysin/Cv/1 |right|CAPTION=Proaerolysin [[1pre]] }} | ||
[[Aerolysin]] (Aer) is a channel-forming toxin from ''Aeromonas hydrophyla''. It uses GPI-anchored proteins on the cell surface as receptors. Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death. It is secreted as an inactive precursor proaerolysin (proAer) which gets cleaved by furin to produce the active Aer. The images at the left and at the right correspond to one representative Aerolysin, ''i.e.'' the crystal structure of Proaerolysin ([[1pre]]). | [[Aerolysin]] (Aer) is a channel-forming toxin from ''Aeromonas hydrophyla''. It uses GPI-anchored proteins on the cell surface as receptors. Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death. It is secreted as an inactive precursor proaerolysin (proAer) which gets cleaved by furin to produce the active Aer. The images at the left and at the right correspond to one representative Aerolysin, ''i.e.'' the crystal structure of Proaerolysin ([[1pre]]). | ||
Revision as of 13:41, 9 December 2010
Aerolysin (Aer) is a channel-forming toxin from Aeromonas hydrophyla. It uses GPI-anchored proteins on the cell surface as receptors. Following binding it forms heptamers which insert into the cell membrane producing channels thus causing cell death. It is secreted as an inactive precursor proaerolysin (proAer) which gets cleaved by furin to produce the active Aer. The images at the left and at the right correspond to one representative Aerolysin, i.e. the crystal structure of Proaerolysin (1pre).
3D Structures of Aerolysin
Aerolysin
Proaerolysin
1pre - proAer
3c0m, 3c0n, 1z52 - proAer (mutant)
3c0o - proAer (mutant)+mannose-6-phosphate
