ATPase: Difference between revisions

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New page: left|200px|thumb|NMR Structure of ATPase [[1mo8]] {{STRUCTURE_1mo8| PDB=1mo8 | SIZE=300| SCENE= |right|CAPTION=ATPase 1mo8 }} ATPase catalyzes the breakdown o...
 
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[[Image:1mo8.png|left|200px|thumb|NMR Structure of ATPase [[1mo8]]]]
[[Image:1mo8.png|left|200px|thumb|NMR Structure of ATPase [[1mo8]]]]
{{STRUCTURE_1mo8|  PDB=1mo8  | SIZE=300| SCENE= |right|CAPTION=ATPase [[1mo8]] }}
{{STRUCTURE_1mo8|  PDB=1mo8  | SIZE=300| SCENE=ATPase/Cv/1 |right|CAPTION=ATPase [[1mo8]] }}


[[ATPase]] catalyzes the breakdown of ATP to ADP and phosphate.  This reaction releases energy which is used by the cell in processes like moving solutes through molecular pumps against a gradient.  NBD is the nucleotide binding domain. MBD is the metal binding domain. The images at the left and at the right correspond to one representative ATPase, ''i.e.'' the NMR structure of rat ATPase ([[1mo8]]).
[[ATPase]] catalyzes the breakdown of ATP to ADP and phosphate.  This reaction releases energy which is used by the cell in processes like moving solutes through molecular pumps against a gradient.  NBD is the nucleotide binding domain. MBD is the metal binding domain. The images at the left and at the right correspond to one representative ATPase, ''i.e.'' the NMR structure of rat ATPase ([[1mo8]]).
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== 3D Structures of ATPase ==
== 3D Structures of ATPase ==


Cu transporting ATPase


2kmv, 2kmx, 2arf – hATPase NBD – human – NMR
=== Cu transporting ATPase ===
2kij - hATPase MBD – NMR
1yjr, 1yjt, 1yju, 1yjv - hATPase  (mutant) 6th soluble domain – NMR
1y3j, 1y3k - hATPase  5th soluble domain – NMR
1s6o, 1s6u - hATPase  2nd soluble domain – NMR
1q8l - hATPase  2nd MBD  – NMR
1aw0, 2aw0 - hATPase  4th MBD  – NMR
1kvi, 1kvj - hATPase  1st MBD  – NMR
3dxs - AtATPase MBD– Arabidopsis thaliana
3voy - AfATPase – Archaeoglobus fulgidus – CryoEM
2k1r - hATPase MBD+ ATOX1 – NMR
2rop, 2g9o, 2ga7 - hATPase MBD – NMR
2rml - BsATPase N-terminal – Bacillus subtilis – NMR
2gcf - sATPase N-terminal - Synechocystis – NMR
2iye - ATPase catalytic fragment – Sulfolobus solfataricus
1fvq, 1fvs - hATPase – NMR


Na/K transporting ATPase
[[2kmv]], [[2kmx]], [[2arf]] – hATPase NBD – human – NMR<br />
[[2kij]] - hATPase MBD – NMR<br />
[[1yjr]], [[1yjt]], [[1yju]], [[1yjv]] - hATPase  (mutant) 6th soluble domain – NMR<br />
[[1y3j]], [[1y3k]] - hATPase  5th soluble domain – NMR<br />
[[1s6o]], [[1s6u]] - hATPase  2nd soluble domain – NMR<br />
[[1q8l]] - hATPase  2nd MBD  – NMR<br />
[[1aw0]], [[2aw0]] - hATPase  4th MBD  – NMR<br />
[[1kvi]], [[1kvj]] - hATPase  1st MBD  – NMR<br />
[[3dxs]] - AtATPase MBD – ''Arabidopsis thaliana''<br />
[[3voy]] - AfATPase – ''Archaeoglobus fulgidus'' – CryoEM<br />
[[2k1r]] - hATPase MBD+ ATOX1 – NMR<br />
[[2rop]], [[2g9o]], [[2ga7]] - hATPase MBD – NMR<br />
[[2rml]] - BsATPase N-terminal – ''Bacillus subtilis'' – NMR<br />
[[2gcf]] - sATPase N-terminal - Synechocystis – NMR<br />
[[2iye]] - ATPase catalytic fragment – ''Sulfolobus solfataricus''<br />
[[1fvq]], [[1fvs]] - hATPase – NMR


3a3y - SaATPase+K+ouabain – Squalus acanthias
3b8e - pATPase a+BeF3 - pig
2hc8 –AfATPase CopA A domain
2b8e - AfATPase CopA NBD
2xze - SaATPase
3kdp, 3b8e – pATPase  – pig
1mo8, 1mo7 - ATPase alpha-1 – rat
1q3i - pATPase NBD


Ca transporting ATPase
=== Na/K transporting ATPase ===


3fgo - rATPase+CPA+AMPPCP – rabbit
[[3a3y]] - SaATPase+K+ouabain – ''Squalus acanthias''<br />
3b9r, 1xp5 - rATPase+AlF4
[[3b8e]] - pATPase a+BeF3 - pig<br />
1wpg - rATPase+MgF4
[[2hc8]] –AfATPase CopA A domain<br />
2zbe – rATPase+BeF3
[[2b8e]] - AfATPase CopA NBD<br />
2zbf - rATPase+BeF3+TG
[[2xze]] - SaATPase<br />
2zbg - rATPase+AlF4+TG
[[3kdp]], [[3b8e]] – pATPase  – pig <br />
2zbd - rATPase+AlF4+ADP+Ca
[[1mo8]], [[1mo7]] - ATPase alpha-1 – rat<br />
2dqs - rATPase+AMPPCP
[[1q3i]] - pATPase NBD
2c88, 2c8k - rATPase+AMPPCP+TG
1vfp - rATPase+AMPPCP
2ear, 2c8l - rATPase+TG
1iwo - rATPase
2agv - rATPase+TG+BHQ
2eas - rATPase+CPA
2eat - rATPase+CPA+GT
2eau - rATPase+CPA+curcumin
3ba6 - rATPase phosphoenzyme intermediate
3fpb - rATPase+ATP+cyclopiazonic acid
3fps, 2oa0 - rATPase+ADP+cyclopiazonic acid
2o9j - rATPase+MgF4+cyclopiazonic acid
1kju - rATPase E2 state
2c9m - rATPase Ca2E1 state
1t5s - rATPase Ca2E1 state+AMPPCP
1t5t - rATPase Ca2E1 state+ADP+AlF4
1su4 - rATPase +2Ca2
2by4 - rATPase HNE2 state+thapsigargin derivative


Zn transporting ATPase


2ofg, 2ofh - sATPase N-terminal – NMR
=== Ca transporting ATPase ===


K+ transporting ATPase
[[3fgo]] - rATPase+CPA+AMPPCP – rabbit<br />
[[3b9r]], [[1xp5]] - rATPase+AlF4<br />
[[1wpg]] - rATPase+MgF4<br />
[[2zbe]] – rATPase+BeF3<br />
[[2zbf]] - rATPase+BeF3+TG<br />
[[2zbg]] - rATPase+AlF4+TG<br />
[[2zbd]] - rATPase+AlF4+ADP+Ca<br />
[[2dqs]] - rATPase+AMPPCP<br />
[[2c88]], [[2c8k]] - rATPase+AMPPCP+TG<br />
[[1vfp]] - rATPase+AMPPCP<br />
[[2ear]], [[2c8l]] - rATPase+TG<br />
[[1iwo]] - rATPase<br />
[[2agv]] - rATPase+TG+BHQ<br />
[[2eas]] - rATPase+CPA<br />
[[2eat]] - rATPase+CPA+GT<br />
[[2eau]] - rATPase+CPA+curcumin<br />
[[3ba6]] - rATPase phosphoenzyme intermediate<br />
[[3fpb]] - rATPase+ATP+cyclopiazonic acid<br />
[[3fps]], [[2oa0]] - rATPase+ADP+cyclopiazonic acid<br />
[[2o9j]] - rATPase+MgF4+cyclopiazonic acid<br />
[[1kju]] - rATPase E2 state<br />
[[2c9m]] - rATPase Ca2E1 state<br />
[[1t5s]] - rATPase Ca2E1 state+AMPPCP<br />
[[1t5t]] - rATPase Ca2E1 state+ADP+AlF4<br />
[[1su4]] - rATPase +2Ca2<br />
[[2by4]] - rATPase HNE2 state+thapsigargin derivative


2a00, 2a29 - EcATPase NBD of KdpB+AMPPNP– Escherichia coli – NMR
1svj, 1u7q - EcATPase NBD of KdpB – NMR


As transporting ATPase
=== Zn transporting ATPase ===


1ii0, 1f48 - EcATPase
[[2ofg]], [[2ofh]] - sATPase N-terminal – NMR
1ihu – EcATPase+Mg+ADP+AlF3
1ii9 - EcATPase+AMPPNP


H+ transporting ATPase


3b8c  - AtATPase C terminal truncated
=== K+ transporting ATPase ===
1mhs - ATPase – Neurospora crassa


Na+ transporting ATPase
[[2a00]], [[2a29]] - EcATPase NBD of KdpB+AMPPNP– ''Escherichia coli'' – NMR<br />
[[1svj]], [[1u7q]] - EcATPase NBD of KdpB – NMR


2db4 - ATPase subunit K – Enterococcus hirae
1yce - ATPase rotor ring – Ilyobacter tartaricus


H/K transporting ATPase
=== As transporting ATPase ===


1iwc, 1iwf - pATPase NBD
[[1ii0]], [[1f48]] - EcATPase<br />
3ixz - pATPase a+AlF4
[[1ihu]] – EcATPase+Mg+ADP+AlF3<br />
[[1ii9]] - EcATPase+AMPPNP


Mg transporting ATPase


3gwi – EcATPase P-1 NBD
=== H+ transporting ATPase ===


Arg/ornithine transporting ATPase
[[3b8c]]  - AtATPase C terminal truncated<br />
[[1mhs]] - ATPase – ''Neurospora crassa''


3md0 – MtATPase+GDP – Mycobacterium tuberculosis
=== Na+ transporting ATPase ===


1kmh - ATPase alpha subunit+tentoxin – spinach
[[2db4]] - ATPase subunit K – ''Enterococcus hirae''<br />
1h8e – cATPase+ADP+AlF4+ADP+SO4 - cow
[[1yce]] - ATPase rotor ring – ''Ilyobacter tartaricus''
1h8h - cATPase+ AMPPNP
 
1efr - cATPase+efrapeptin
=== H/K transporting ATPase ===
3fks – ATPase – yeast
 
3ea0 – ATPase ParA, fragment – Chlorobium tepidum
[[1iwc]], [[1iwf]] - pATPase NBD <br />
2qen – ATPase (mutant) Walker-type – Pyrococcus abyssi
[[3ixz]] - pATPase a+AlF4
3cf0, 3cf1, 3cf3 – mATPase  NBD+ADP – mouse
 
3cf2 - mATPase NBD+ADP+AMP-PNP
 
2r31, 2p4x – PdATPase ATP12 – Paracoccus denitrificans
=== Mg transporting ATPase ===
2zd2 – PdATPase (mutant) ATP12
 
1d8s – EcATPase F1
[[3gwi]] – EcATPase P-1 NBD
1vdz – ATPase subunit A – Pyrococcus horikoshii
 
 
=== Arg/ornithine transporting ATPase ===
 
[[3md0]] – MtATPase+GDP – ''Mycobacterium tuberculosis''<br />
[[1kmh]] - ATPase alpha subunit+tentoxin – spinach<br />
[[1h8e]] – cATPase+ADP+AlF4+ADP+SO4 - cow<br />
[[1h8h]] - cATPase+ AMPPNP<br />
[[1efr]] - cATPase+efrapeptin<br />
[[3fks]] – ATPase – yeast<br />
[[3ea0]] – ATPase ParA, fragment – ''Chlorobium tepidum''<br />
[[2qen]] – ATPase (mutant) Walker-type – ''Pyrococcus abyssi''<br />
[[3cf0]], [[3cf1]], [[3cf3]] – mATPase  NBD+ADP – mouse<br />
[[3cf2]] - mATPase NBD+ADP+AMP-PNP<br />
[[2r31]], [[2p4x]] – PdATPase ATP12 – ''Paracoccus denitrificans''<br />
[[2zd2]] – PdATPase (mutant) ATP12<br />
[[1d8s]] – EcATPase F1<br />
[[1vdz]] – ATPase subunit A – ''Pyrococcus horikoshii''
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