Tacrine: Difference between revisions

Tacrine is an [[Acetylcholinesterase]] (AChE) inhibitor. It binds to the active site of <scene name='Tacrine/Ache/1'>AChE</scene>, utilizing many of the same residues which <scene name='Tacrine/Ac/1'>bind and break down acetylcholine</scene>. By inhibiting AChE, the important neurotransmitter, [[acetylcholine]], is degraded at a slower rate, helping reverse the marked decrease in neuronal function evident in [[Alzheimer's Disease]] patients. Tacrine <scene name='Tacrine/Bound/2'>primarily interacts with residues</scene> Phe 330, His 440, Trp 84, & Ser 200 in tightly binding to the AChE binding site via pi stacking interactions. It is clearly visible how <scene name='Tacrine/Inter/3'>Tacrine interferes</scene> with the binding of acetylcholine, outcompeting acetylcholine for nearly the same space in the active site. <ref>PMID:8415649</ref>

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