Imatinib: Difference between revisions
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===Mechanism of Action=== | ===Mechanism of Action=== | ||
In chronic myelogenous leukemia, the Philadelphia chromosome leads to a fusion protein of abl with bcr (breakpoint cluster region), termed bcr-abl. As this is now a constitutively active tyrosine kinase, imatinib is used to decrease bcr-abl activity. | |||
<ref>doi: 10.1107/S0907444906047287</ref> | <ref>doi: 10.1107/S0907444906047287</ref> | ||
