Troponin

File:1yv0.png

Crystal Structure of Troponin 1yv0

Troponin (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits: TnC causes conformational change in TnI when it binds to calcium ions. TnT binds to tropomyosin and TnI binds to actin which is found in thin muscle filaments. The images at the left and at the right correspond to one representative Tn, i.e. the crystal structure of complex Troponin C/Troponin I/Troponin T (1yv0).

3D Structures of Troponin

Troponin C+Troponin I+Troponin T

2w49 – cTnC+cTnI+cTnT+tropomyosin+actin – chicken
1ytz - cTnC+cTnI+cTnT+Ca++
1yv0 - cTnC+cTnI+cTnT
1j1d, 1j1e – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca++ - human

Troponin C+Troponin I

2krd – hTnC+hTnI – NMR
1ozs - hTnC C-terminal+hTnI N-terminal – NMR
1lxf, 1mxl - hTnC N-terminal+hTnI fragment
2kgb – hTnC (mutant) regulatory domain+TnI
1sbj – cTnC C-terminal+cTnI N-terminal+Mg++ - NMR
1scv, 1fi5, 1blq - cTnC C-terminal+cTnI N-terminal – NMR
1npq - cTnC (mutant) N-terminal+cTnI fragment+rhodamine
1jc2 - cTnC C-terminal+cTnI N-terminal
1a2x - rTnC +rTnI fragment – rabbit

Troponin C

2kdh – hTnC+green tea polyphenol – NMR
2kfx – hTnC (mutant) N-terminal+Ca+naphthalene derivative
2jt0, 2jtz, 2jt8, 2jt3 – hTnC (mutant) – NMR
2jxl - hTnC (mutant) N-terminal – NMR
1wrk, 1wrl - hTnC (mutant) N-terminal+trifluoperazine
1spy - hTnC N-terminal– NMR
1ih0 - hTnC C-terminal+EMD 57033 – NMR
1ap4 - hTnC N-terminal+Ca++ – NMR
1la0, 4tnc – cTnC+Ca++
1dtl – cTnC (mutant)+Ca++ +bepridil
1skt, 1zac, 2ctn - cTnC N-terminal – NMR
1aj4 - cTnC (mutant) +Ca++ – NMR
1ctn - cTnC C-terminal – NMR
1avs - cTnC N-terminal+Ca++
1smg, 1tnq - cTnC N-terminal+Ca++ - NMR
1ncy – cTnC+Mn++
1ncx, 1ncz, 1top – cTnC
1pon, 1cta, 1ctd – cTnC fragment – NMR
1tnp - cTnC N-terminal – NMR
1tnw, 1tnx - cTnC +Ca++ - NMR
1trf - tTnC N-terminal+Ca++ - turkey – NMR
5tnc - tTnC
2k2a - TnC C-terminal – Lethocerus indicus – NMR
2jnf – TnC – fly – NMR
1r2u, 1r6p - TnC N-terminal – trout – NMR
1tcf – rTnC+Ca++
1tn4, 2tn4 – rTnC (mutant)+Ca++

Troponin I

2jpw – TnI biphosphorylated – mouse – NMR
1vdi – cTnI – NMR
1vdj – cTnI+Ca++ - NMR

Troponin T

2z5h – yTnT fragment+tropomyosin – yeast

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Joel L. Sussman, Michal Harel