Lipase: Difference between revisions
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<applet load='1hpl3.pdb' size='300' frame='true' align='right' scene="Lipase/Lipase_starting_scene/2" caption='Crystal Structure of Horse Pancreatic Lipase, [[1hpl]]' /> | <applet load='1hpl3.pdb' size='300' frame='true' align='right' scene="Lipase/Lipase_starting_scene/2" caption='Crystal Structure of Horse Pancreatic Lipase, [[1hpl]]' /> | ||
'''Lipase''' is a subclass of esterases which catalyzes the hydrolysis of ester bonds in lipid substrates and is essential for fat digestion. It is primarily produced in the pancreas, but can be found in the mouth and stomach as well. The scene name='Lipase/Lipase_starting_scene/2'>lipase</scene> typically digests fat lipids into monoglycerides and free fatty acids, with the resulting monomers subsequently shuttled to the small intestine and eventually absorbed into the lymphatic system. | '''Lipase''' is a subclass of esterases which catalyzes the hydrolysis of ester bonds in lipid substrates and is essential for fat digestion. It is primarily produced in the pancreas, but can be found in the mouth and stomach as well. The <scene name='Lipase/Lipase_starting_scene/2'>lipase</scene> typically digests fat lipids into monoglycerides and free fatty acids, with the resulting monomers subsequently shuttled to the small intestine and eventually absorbed into the lymphatic system. | ||
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== 3D Structures of Lipase == | == 3D Structures of Lipase == | ||
=== | ===Eukaryote natives: === | ||
[[1hpl]] – hLip – horse <br /> | [[1hpl]] – hLip – horse <br /> | ||
[[1hlg]] – hLip – human - gastric<br /> | [[1hlg]] – hLip – human - gastric<br /> | ||
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[[1f6w]] - BAL – catalytic domain<br /> | [[1f6w]] - BAL – catalytic domain<br /> | ||
[[1gpl]] – Lip – guinea pig – RP2 (lipase related protein 2) <br /> | [[1gpl]] – Lip – guinea pig – RP2 (lipase related protein 2) <br /> | ||
[[2bce]] – cBAL (mutant)<br /> | |||
[[3o0d]] – Lip – ''Yarrowia lipolytica'' | |||
=== | ===Prokaryote natives: === | ||
[[3guu]], [[1lbs]], [[1lbt]], [[1tca]], [[1tcb]], [[1tcc]] – CaLipA – ''Candida antarctica''<br /> | [[3guu]], [[1lbs]], [[1lbt]], [[1tca]], [[1tcb]], [[1tcc]] – CaLipA – ''Candida antarctica''<br /> | ||
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[[1gz7]], [[1lpm]], [[1lps]]– CrLip 2 – ''Candida rugosa'' - closed state<br /> | [[1gz7]], [[1lpm]], [[1lps]]– CrLip 2 – ''Candida rugosa'' - closed state<br /> | ||
[[1crl]], [[1trh]] – CrLip – open state<br /> | [[1crl]], [[1trh]] – CrLip – open state<br /> | ||
[[1llf]] – Lip – ''Candida cylindracea''<br /> | |||
[[3g7n]] – Lip - ''Penicillium expansum''<br /> | [[3g7n]] – Lip - ''Penicillium expansum''<br /> | ||
[[1tia]] - Lip – ''Penicillium camemberti''<br /> | [[1tia]] - Lip – ''Penicillium camemberti''<br /> | ||
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[[2zj6]], [[2zj7]] – PsLip (mutant) <br /> | [[2zj6]], [[2zj7]] – PsLip (mutant) <br /> | ||
[[2z8z]] – PsLip(mutant) – closed state<br /> | [[2z8z]] – PsLip(mutant) – closed state<br /> | ||
[[3lip]] - Lip - ''Pseudomonas cepacia'' – open state<br /> | [[3lip]], [[3a6z]] - Lip - ''Pseudomonas cepacia'' – open state<br /> | ||
[[1qge]], [[1tah]] – Lip – ''Pseudomonas glumae''<br /> | [[1qge]], [[1tah]] – Lip – ''Pseudomonas glumae''<br /> | ||
[[2w22]] – Lip – ''Geobacillus thermocatenulatus''<br /> | [[2w22]] – Lip – ''Geobacillus thermocatenulatus''<br /> | ||
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[[2ory]] – Lip – ''Photobacterium lypoliticum''<br /> | [[2ory]] – Lip – ''Photobacterium lypoliticum''<br /> | ||
[[2z5g]], [[2dsn]] – Lip T1 – ''Geobacillus zalihae''<br /> | [[2z5g]], [[2dsn]] – Lip T1 – ''Geobacillus zalihae''<br /> | ||
[[3p94]] – Lip – ''Parabacteroides distasonis'' | |||
