1u71: Difference between revisions

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{{Seed}}
[[Image:1u71.png|left|200px]]
[[Image:1u71.png|left|200px]]


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{{ABSTRACT_PUBMED_15681865}}
{{ABSTRACT_PUBMED_15681865}}


==Disease==
==About this Structure==
Known disease associated with this structure: Anemia, megaloblastic, due to DHFR deficiency (1) OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=126060 126060]]
[[1u71]] is a 1 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U71 OCA].


==About this Structure==
==See Also==
1U71 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U71 OCA].
*[[Dihydrofolate reductase]]


==Reference==
==Reference==
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[[Category: Pangborn, W.]]
[[Category: Pangborn, W.]]
[[Category: Human dhfr l22r variant]]
[[Category: Human dhfr l22r variant]]
 
[[Category: Oxidoreductase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:18:21 2009''

Revision as of 19:47, 26 December 2010

File:1u71.png

Template:STRUCTURE 1u71

Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH

Template:ABSTRACT PUBMED 15681865

About this Structure

1u71 is a 1 chain structure of Dihydrofolate reductase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Cody V, Luft JR, Pangborn W. Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Acta Crystallogr D Biol Crystallogr. 2005 Feb;61(Pt 2):147-55. Epub 2005, Jan 19. PMID:15681865 doi:https://dx.doi.org/10.1107/S0907444904030422

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