3ghw: Difference between revisions

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Revision as of 20:51, 26 December 2010

File:3ghw.png

Template:STRUCTURE 3ghw

Human dihydrofolate reductase inhibitor complex

Template:ABSTRACT PUBMED 19719239

About this Structure

3ghw is a 1 chain structure of Dihydrofolate reductase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Gangjee A, Li W, Kisliuk RL, Cody V, Pace J, Piraino J, Makin J. Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. J Med Chem. 2009 Aug 13;52(15):4892-902. PMID:19719239 doi:10.1021/jm900490a

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