1tl8: Difference between revisions
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[[Image:1tl8.png|left|200px]] | [[Image:1tl8.png|left|200px]] | ||
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{{ABSTRACT_PUBMED_16033260}} | {{ABSTRACT_PUBMED_16033260}} | ||
== | ==About this Structure== | ||
[[1tl8]] is a 4 chain structure of [[Topoisomerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TL8 OCA]. | |||
== | ==See Also== | ||
*[[Topoisomerase]] | |||
==Reference== | ==Reference== | ||
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[[Category: Poison]] | [[Category: Poison]] | ||
[[Category: Topoisomerase i]] | [[Category: Topoisomerase i]] | ||
Revision as of 21:06, 26 December 2010
Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex
Template:ABSTRACT PUBMED 16033260
About this Structure
1tl8 is a 4 chain structure of Topoisomerase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Ioanoviciu A, Antony S, Pommier Y, Staker BL, Stewart L, Cushman M. Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis. J Med Chem. 2005 Jul 28;48(15):4803-14. PMID:16033260 doi:10.1021/jm050076b
