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New page: left|200px<br /> <applet load="2rll" size="450" color="white" frame="true" align="right" spinBox="true" caption="2rll" /> '''CCR5 Nt(7-15)'''<br /> ==Overview== The CC...
 
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[[Image:2rll.gif|left|200px]]<br />
[[Image:2rll.jpg|left|200px]]<br /><applet load="2rll" size="350" color="white" frame="true" align="right" spinBox="true"  
<applet load="2rll" size="450" color="white" frame="true" align="right" spinBox="true"  
caption="2rll" />
caption="2rll" />
'''CCR5 Nt(7-15)'''<br />
'''CCR5 Nt(7-15)'''<br />
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==Overview==
==Overview==
The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and, facilitates HIV-1 entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on, gp120. We applied nuclear magnetic resonance and crystallographic, techniques to analyze the structure of the CCR5 N terminus and that of the, tyrosine-sulfated antibody 412d in complex with gp120 and CD4. The, conformations of tyrosine-sulfated regions of CCR5 (alpha-helix) and 412d, (extended loop) are surprisingly different. Nonetheless, a critical, sulfotyrosine on CCR5 and on 412d induces similar structural, rearrangements in gp120. These results now provide a framework for, understanding HIV-1 interactions with the CCR5 N terminus during viral, entry and define a conserved site on gp120, whose recognition of, sulfotyrosine engenders posttranslational mimicry by the immune system.
The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and, facilitates HIV-1 entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on, gp120. We applied nuclear magnetic resonance and crystallographic, techniques to analyze the structure of the CCR5 N terminus and that of the, tyrosine-sulfated antibody 412d in complex with gp120 and CD4. The, conformations of tyrosine-sulfated regions of CCR5 (alpha-helix) and 412d, (extended loop) are surprisingly different. Nonetheless, a critical, sulfotyrosine on CCR5 and on 412d induces similar structural, rearrangements in gp120. These results now provide a framework for, understanding HIV-1 interactions with the CCR5 N terminus during viral, entry and define a conserved site on gp120, whose recognition of, sulfotyrosine engenders posttranslational mimicry by the immune system.
==Disease==
Known diseases associated with this structure: HIV infection, susceptibility/resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601373 601373]], West nile virus, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601373 601373]]


==About this Structure==
==About this Structure==
2RLL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2RLL OCA].  
2RLL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLL OCA].  


==Reference==
==Reference==
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[[Category: transmembrane]]
[[Category: transmembrane]]


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