2uuu: Difference between revisions
New page: left|200px<br /> <applet load="2uuu" size="450" color="white" frame="true" align="right" spinBox="true" caption="2uuu, resolution 1.95Å" /> '''ALKYLDIHYDROXYACETO... |
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==About this Structure== | ==About this Structure== | ||
2UUU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]] with FAD and PL3 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.26 2.5.1.26]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UUU OCA]]. | 2UUU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]] with FAD and PL3 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Alkylglycerone-phosphate_synthase Alkylglycerone-phosphate synthase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.26 2.5.1.26]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UUU OCA]]. | ||
==Reference== | ==Reference== | ||
The crucial step in ether phospholipid biosynthesis: structural basis of a noncanonical reaction associated with a peroxisomal disorder., Razeto A, Mattiroli F, Carpanelli E, Aliverti A, Pandini V, Coda A, Mattevi A, Structure. 2007 Jun;15(6):683-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17562315 17562315] | The crucial step in ether phospholipid biosynthesis: structural basis of a noncanonical reaction associated with a peroxisomal disorder., Razeto A, Mattiroli F, Carpanelli E, Aliverti A, Pandini V, Coda A, Mattevi A, Structure. 2007 Jun;15(6):683-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17562315 17562315] | ||
[[Category: Alkylglycerone-phosphate synthase]] | |||
[[Category: Dictyostelium discoideum]] | [[Category: Dictyostelium discoideum]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:24:32 2007'' | ||
Revision as of 09:19, 30 October 2007
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ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE IN P212121
Overview
Ether phospholipids are essential constituents of eukaryotic cell, membranes. Rhizomelic chondrodysplasia punctata type 3 is a severe, peroxisomal disorder caused by inborn deficiency of, alkyldihydroxyacetonephosphate synthase (ADPS). The enzyme carries out the, most characteristic step in ether phospholipid biosynthesis: formation of, the ether bond. The crystal structure of ADPS from Dictyostelium, discoideum shows a fatty-alcohol molecule bound in a narrow hydrophobic, tunnel, specific for aliphatic chains of 16 carbons. Access to the tunnel, is controlled by a flexible loop and a gating helix at the, protein-membrane interface. Structural and mutagenesis investigations, identify a cluster of hydrophilic catalytic residues, including an, essential tyrosine, possibly involved in ... [(full description)]
About this Structure
2UUU is a [Single protein] structure of sequence from [Dictyostelium discoideum] with FAD and PL3 as [ligands]. Active as [Alkylglycerone-phosphate synthase], with EC number [2.5.1.26]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The crucial step in ether phospholipid biosynthesis: structural basis of a noncanonical reaction associated with a peroxisomal disorder., Razeto A, Mattiroli F, Carpanelli E, Aliverti A, Pandini V, Coda A, Mattevi A, Structure. 2007 Jun;15(6):683-92. PMID:17562315
Page seeded by OCA on Tue Oct 30 11:24:32 2007
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Alkylglycerone-phosphate synthase
- Dictyostelium discoideum
- Single protein
- Aliverti, A.
- Carpanelli, E.
- Coda, A.
- Mattevi, A.
- Mattiroli, F.
- Pandini, V.
- Razeto, A.
- FAD
- PL3
- Biosynthesis of phospholipids
- Fad
- Flavin
- Flavoprotein
- Lipid synthesis
- Peroxisomal disorder
- Peroxisome
- Plasmalogens
- Rhizomelic chondrodysplasia punctata
- Transferase
