2o3d: Difference between revisions
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'''Structure of human SF2/ASF RNA recognition motif 2 (RRM2)'''<br /> | '''Structure of human SF2/ASF RNA recognition motif 2 (RRM2)'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2O3D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 2O3D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3D OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: rrm domain]] | [[Category: rrm domain]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:53:01 2008'' | ||
Revision as of 10:53, 23 January 2008
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Structure of human SF2/ASF RNA recognition motif 2 (RRM2)
Overview
The serine/arginine-rich (SR) protein splicing factor 2/alternative, splicing factor (SF2/ASF) has a role in splicing, stability, export and, translation of messenger RNA. Here, we present the structure of the RNA, recognition motif (RRM) 2 from SF2/ASF, which has an RRM fold with a, considerably extended loop 5 region, containing a two-stranded beta-sheet., The loop 5 extension places the previously identified SR protein kinase 1, docking sequence largely within the RRM fold. We show that RRM2 binds to, RNA in a new way, by using a tryptophan within a conserved SWQLKD motif, that resides on helix alpha1, together with amino acids from strand beta2, and a histidine on loop 5. The linker connecting RRM1 and RRM2 contains, arginine residues, which provide a binding site for the mRNA export factor, TAP, and when TAP binds to this region it displaces RNA bound to RRM2.
About this Structure
2O3D is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural and functional analysis of RNA and TAP binding to SF2/ASF., Tintaru AM, Hautbergue GM, Hounslow AM, Hung ML, Lian LY, Craven CJ, Wilson SA, EMBO Rep. 2007 Aug;8(8):756-62. Epub 2007 Jul 13. PMID:17668007
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