3hhm: Difference between revisions

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{{Seed}}
[[Image:3hhm.png|left|200px]]
[[Image:3hhm.png|left|200px]]


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{{ABSTRACT_PUBMED_19805105}}
{{ABSTRACT_PUBMED_19805105}}


==Disease==
==About this Structure==
Known disease associated with this structure: Breast cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171834 171834]], Colorectal cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171834 171834]], Gastric cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171834 171834]], Hepatocellular carcinoma, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171834 171834]], Keratosis, seborrheic, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171834 171834]], Nevus, epidermal OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171834 171834]], Nonsmall cell lung cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171834 171834]], Ovarian cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171834 171834]]
[[3hhm]] is a 2 chain structure of [[Phosphoinositide 3-Kinases]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHM OCA].  


==About this Structure==
==See Also==
3HHM is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHM OCA].
*[[Phosphoinositide 3-Kinases]]


==Reference==
==Reference==
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[[Category: Transferase/oncoprotein complex]]
[[Category: Transferase/oncoprotein complex]]
[[Category: Wortmannin]]
[[Category: Wortmannin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 09:50:12 2009''

Revision as of 01:25, 27 December 2010

File:3hhm.png

Template:STRUCTURE 3hhm

Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin

Template:ABSTRACT PUBMED 19805105

About this Structure

3hhm is a 2 chain structure of Phosphoinositide 3-Kinases with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Mandelker D, Gabelli SB, Schmidt-Kittler O, Zhu J, Cheong I, Huang CH, Kinzler KW, Vogelstein B, Amzel LM. A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):16996-7001. Epub 2009 Sep 23. PMID:19805105

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