3eig: Difference between revisions

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Revision as of 01:28, 27 December 2010

File:3eig.png

Template:STRUCTURE 3eig

Crystal structure of a methotrexate-resistant mutant of human dihydrofolate reductase

Template:ABSTRACT PUBMED 19478082

About this Structure

3eig is a 1 chain structure of Dihydrofolate reductase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Volpato JP, Yachnin BJ, Blanchet J, Guerrero V, Poulin L, Fossati E, Berghuis AM, Pelletier JN. Multiple conformers in active site of human dihydrofolate reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance. J Biol Chem. 2009 Jul 24;284(30):20079-89. Epub 2009 May 28. PMID:19478082 doi:10.1074/jbc.M109.018010

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